Sensitivity Enhancement Using Surface Plasmon Resonance Sensor for Colorectal Detection by Employing Heterostructure

This article proposes a surface plasmon resonance (SPR) sensor based on heterostructure (MXene/h-BN/BP) for colorectal cancer detection. Surface plasmons (SPs) have been excited using the prism-based setup. The silver (Ag) layer on the CaF₂ prism makes up the structure of the proposed sensor. To increase the stability of the Ag layer, a heterostructure layer is applied on top. Both normal and colorectal tissues are used as the analyte medium to detect colorectal cancer. The transfer matrix method has been used to carry out the sensor’s numerical simulations. The proposed sensor’s performance is determined by its sensitivity, detection accuracy (DA), and figure of merit (FoM), which takes into account the SPR curve’s dip strength and full width at half maxima (FWHM). The sensitivity and FoM 315.30°/RIU and 52.34/RIU are obtained, respectively. The maximal sensitivity of 322.21°/RIU is achieved. Additionally, the penetration depth (PD) is achieved at 218.81 nm with the normal tissue. The proposed sensor would be a good candidate for biosensors and medical diagnostics.