{"title":"基于BifeO3和2D材料复合结构的高性能SPR生物传感器的设计","authors":"Younes Mousania, Salman Karimi, Ali Farmani","doi":"10.1007/s11468-024-02516-w","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, we present an improved surface plasmon resonance (SPR)-based optical biosensor specifically designed to identify and detect medical analytes, with a particular focus on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The proposed biosensor utilizes a hybrid structure of Au-Ag-BiFeO3-Graphene on a BK7 prism, employing a modified Kretschmann configuration. This structure has been meticulously optimized to ensure that the reflectivity curve of the surface plasmon resonance is minimized to zero, enhancing the sensor’s performance. The design and analysis were conducted using ANSYS Lumbrical software, leveraging the Finite-Difference Time-Domain (FDTD) method for precise simulation. The improved results have been obtained by optimizing the thickness of the gold, silver, and BifeO3 layers, fine-tuning the meshes of different areas of the structure, and adjusting the angle at which light strikes the prism. The performance metrics of the proposed biosensor are impressive, with sensitivity, detection accuracy (DA), figure of merit (FOM), quality factor (QF), combined sensitive factor (CSF), and also the limit of detection (LOD) obtained as 454.1 [deg/RIU], 1.34 [1/deg], 139.95 [RIU<sup>−1</sup>], 153.62 [RIU<sup>−1</sup>], 126.66 and 2.20 × 10<sup>−6</sup>, respectively. The biosensor presented in this paper is practical and capable of construction and development and hopes to create a new horizon for the detection of bio-analytes.</p></div>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"20 9","pages":"7209 - 7228"},"PeriodicalIF":4.3000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Designing High-Performance SPR Biosensor Using Hybrid Structure of BifeO3 and 2D Material for SARS-CoV-2 Detection\",\"authors\":\"Younes Mousania, Salman Karimi, Ali Farmani\",\"doi\":\"10.1007/s11468-024-02516-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, we present an improved surface plasmon resonance (SPR)-based optical biosensor specifically designed to identify and detect medical analytes, with a particular focus on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The proposed biosensor utilizes a hybrid structure of Au-Ag-BiFeO3-Graphene on a BK7 prism, employing a modified Kretschmann configuration. This structure has been meticulously optimized to ensure that the reflectivity curve of the surface plasmon resonance is minimized to zero, enhancing the sensor’s performance. The design and analysis were conducted using ANSYS Lumbrical software, leveraging the Finite-Difference Time-Domain (FDTD) method for precise simulation. The improved results have been obtained by optimizing the thickness of the gold, silver, and BifeO3 layers, fine-tuning the meshes of different areas of the structure, and adjusting the angle at which light strikes the prism. The performance metrics of the proposed biosensor are impressive, with sensitivity, detection accuracy (DA), figure of merit (FOM), quality factor (QF), combined sensitive factor (CSF), and also the limit of detection (LOD) obtained as 454.1 [deg/RIU], 1.34 [1/deg], 139.95 [RIU<sup>−1</sup>], 153.62 [RIU<sup>−1</sup>], 126.66 and 2.20 × 10<sup>−6</sup>, respectively. The biosensor presented in this paper is practical and capable of construction and development and hopes to create a new horizon for the detection of bio-analytes.</p></div>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":\"20 9\",\"pages\":\"7209 - 7228\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11468-024-02516-w\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s11468-024-02516-w","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Designing High-Performance SPR Biosensor Using Hybrid Structure of BifeO3 and 2D Material for SARS-CoV-2 Detection
In this study, we present an improved surface plasmon resonance (SPR)-based optical biosensor specifically designed to identify and detect medical analytes, with a particular focus on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The proposed biosensor utilizes a hybrid structure of Au-Ag-BiFeO3-Graphene on a BK7 prism, employing a modified Kretschmann configuration. This structure has been meticulously optimized to ensure that the reflectivity curve of the surface plasmon resonance is minimized to zero, enhancing the sensor’s performance. The design and analysis were conducted using ANSYS Lumbrical software, leveraging the Finite-Difference Time-Domain (FDTD) method for precise simulation. The improved results have been obtained by optimizing the thickness of the gold, silver, and BifeO3 layers, fine-tuning the meshes of different areas of the structure, and adjusting the angle at which light strikes the prism. The performance metrics of the proposed biosensor are impressive, with sensitivity, detection accuracy (DA), figure of merit (FOM), quality factor (QF), combined sensitive factor (CSF), and also the limit of detection (LOD) obtained as 454.1 [deg/RIU], 1.34 [1/deg], 139.95 [RIU−1], 153.62 [RIU−1], 126.66 and 2.20 × 10−6, respectively. The biosensor presented in this paper is practical and capable of construction and development and hopes to create a new horizon for the detection of bio-analytes.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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