{"title":"设计超灵敏的NIR-II SERS纳米探针：通过等离子体工程实现","authors":"Yifan Wu, Wenhao Zhou, Baihong An","doi":"10.1007/s11468-024-02749-9","DOIUrl":null,"url":null,"abstract":"<div><p>The second near-infrared (NIR-II, 1000–1700 nm) window is advantageous for bioimaging due to its deep tissue penetration and low autofluorescence. Despite these benefits, creating highly sensitive surface-enhanced Raman scattering (SERS) nanoprobes in this range is challenging. This study introduces an ultra-sensitive SERS nanoprobe developed using plasmonic engineering. We selected the commercial Raman dye IR1061, with an absorption peak at 1061 nm, and synthesized gold nanotriangles (AuNTs) to absorb visible light and transfer energy to NIR-II phonons. The combination of IR1061 and AuNTs significantly improved the nanoprobe's sensitivity to 116 fM in the NIR-II window, due to enhanced electromagnetic fields and SERS effects. Theoretical analysis shows AuNTs have stronger electromagnetic hotspots than gold nanorods, enhancing SERS sensitivity. The nanoprobe penetrates pig tissue over 4 mm and agarose gels up to 5 cm. This work presents a novel approach to ultra-sensitive NIR-II SERS nanoprobes for bioimaging and diagnostics. It can not only overcome the bottleneck of traditional imaging technology, but also provide strong support for high-resolution imaging of deep tissues and provide more accurate information for clinical diagnosis and treatment.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"20 9","pages":"6939 - 6950"},"PeriodicalIF":4.3000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Designing Ultrasensitive NIR-II SERS Nanoprobes: Achieved via Plasmonic Engineering\",\"authors\":\"Yifan Wu, Wenhao Zhou, Baihong An\",\"doi\":\"10.1007/s11468-024-02749-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The second near-infrared (NIR-II, 1000–1700 nm) window is advantageous for bioimaging due to its deep tissue penetration and low autofluorescence. Despite these benefits, creating highly sensitive surface-enhanced Raman scattering (SERS) nanoprobes in this range is challenging. This study introduces an ultra-sensitive SERS nanoprobe developed using plasmonic engineering. We selected the commercial Raman dye IR1061, with an absorption peak at 1061 nm, and synthesized gold nanotriangles (AuNTs) to absorb visible light and transfer energy to NIR-II phonons. The combination of IR1061 and AuNTs significantly improved the nanoprobe's sensitivity to 116 fM in the NIR-II window, due to enhanced electromagnetic fields and SERS effects. Theoretical analysis shows AuNTs have stronger electromagnetic hotspots than gold nanorods, enhancing SERS sensitivity. The nanoprobe penetrates pig tissue over 4 mm and agarose gels up to 5 cm. This work presents a novel approach to ultra-sensitive NIR-II SERS nanoprobes for bioimaging and diagnostics. It can not only overcome the bottleneck of traditional imaging technology, but also provide strong support for high-resolution imaging of deep tissues and provide more accurate information for clinical diagnosis and treatment.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":\"20 9\",\"pages\":\"6939 - 6950\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11468-024-02749-9\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s11468-024-02749-9","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Designing Ultrasensitive NIR-II SERS Nanoprobes: Achieved via Plasmonic Engineering
The second near-infrared (NIR-II, 1000–1700 nm) window is advantageous for bioimaging due to its deep tissue penetration and low autofluorescence. Despite these benefits, creating highly sensitive surface-enhanced Raman scattering (SERS) nanoprobes in this range is challenging. This study introduces an ultra-sensitive SERS nanoprobe developed using plasmonic engineering. We selected the commercial Raman dye IR1061, with an absorption peak at 1061 nm, and synthesized gold nanotriangles (AuNTs) to absorb visible light and transfer energy to NIR-II phonons. The combination of IR1061 and AuNTs significantly improved the nanoprobe's sensitivity to 116 fM in the NIR-II window, due to enhanced electromagnetic fields and SERS effects. Theoretical analysis shows AuNTs have stronger electromagnetic hotspots than gold nanorods, enhancing SERS sensitivity. The nanoprobe penetrates pig tissue over 4 mm and agarose gels up to 5 cm. This work presents a novel approach to ultra-sensitive NIR-II SERS nanoprobes for bioimaging and diagnostics. It can not only overcome the bottleneck of traditional imaging technology, but also provide strong support for high-resolution imaging of deep tissues and provide more accurate information for clinical diagnosis and treatment.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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