{"title":"基于激光诱导石墨烯集成电极的智能手机电化学传感器用于牛肉和牛奶中磺胺的现场检测","authors":"Qian Zeng, Yangping Wen, Weiqiang Li, Hongyu Xiao, Xiaoqin Fu, Zhenna Shi, Anna Li, Jingye Liang, Chaoli Tan, Qihua Xu, Kaijie Tang","doi":"10.1007/s00604-025-07538-7","DOIUrl":null,"url":null,"abstract":"<div><p>Sulfadimidine (SM2), a potentially carcinogenic sulfonamides, poses a threat to food safety. In this study, a portable electrochemical sensing platform integrated with a smartphone is developed for on-site sulfadimidine (SM2) detection. The electrode utilizes a flexible three-electrode system based on laser-induced porous graphene (LIPG), fabricated via CO₂ laser etching of polyimide (PI) film. The platform is wirelessly connected to a portable electrochemical workstation and smartphone via Bluetooth. Laser parameters, including power and etching depth, are optimized to improve electrochemical performance. The optimized LIPG electrode exhibits significantly improved sensitivity—2.87 and 10.87-fold higher than screen-printed carbon electrode (SPCE) and glassy carbon electrode (GCE), respectively—along with excellent stability (RSD < 0.46% over 99 cycles) and a rapid 10 s response time. Quantitative detection of SM2 demonstrates good linearity (3 – 110 μM, <i>R</i><sup>2</sup> = 0.999), with low limits of detection (LOD) of 0.03 μM and quantification (LOQ) of 0.1 μM. The method is validated in spiked beef (recovery 93.34% – 103.70%) and milk (recovery 98.50% – 100.80%), confirming its practical applicability. This work is novel in systematically linking laser processing parameters to LIPG electrochemical performance and significant in demonstrating a field-deployable, cost-effective, and smartphone-enabled strategy for monitoring SM2 residues.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Smartphone electrochemical sensor based on laser-induced graphene integrated electrode for on-site sulfadimidine detection in beef and milk\",\"authors\":\"Qian Zeng, Yangping Wen, Weiqiang Li, Hongyu Xiao, Xiaoqin Fu, Zhenna Shi, Anna Li, Jingye Liang, Chaoli Tan, Qihua Xu, Kaijie Tang\",\"doi\":\"10.1007/s00604-025-07538-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Sulfadimidine (SM2), a potentially carcinogenic sulfonamides, poses a threat to food safety. In this study, a portable electrochemical sensing platform integrated with a smartphone is developed for on-site sulfadimidine (SM2) detection. The electrode utilizes a flexible three-electrode system based on laser-induced porous graphene (LIPG), fabricated via CO₂ laser etching of polyimide (PI) film. The platform is wirelessly connected to a portable electrochemical workstation and smartphone via Bluetooth. Laser parameters, including power and etching depth, are optimized to improve electrochemical performance. The optimized LIPG electrode exhibits significantly improved sensitivity—2.87 and 10.87-fold higher than screen-printed carbon electrode (SPCE) and glassy carbon electrode (GCE), respectively—along with excellent stability (RSD < 0.46% over 99 cycles) and a rapid 10 s response time. Quantitative detection of SM2 demonstrates good linearity (3 – 110 μM, <i>R</i><sup>2</sup> = 0.999), with low limits of detection (LOD) of 0.03 μM and quantification (LOQ) of 0.1 μM. The method is validated in spiked beef (recovery 93.34% – 103.70%) and milk (recovery 98.50% – 100.80%), confirming its practical applicability. This work is novel in systematically linking laser processing parameters to LIPG electrochemical performance and significant in demonstrating a field-deployable, cost-effective, and smartphone-enabled strategy for monitoring SM2 residues.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"192 10\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-025-07538-7\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07538-7","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Smartphone electrochemical sensor based on laser-induced graphene integrated electrode for on-site sulfadimidine detection in beef and milk
Sulfadimidine (SM2), a potentially carcinogenic sulfonamides, poses a threat to food safety. In this study, a portable electrochemical sensing platform integrated with a smartphone is developed for on-site sulfadimidine (SM2) detection. The electrode utilizes a flexible three-electrode system based on laser-induced porous graphene (LIPG), fabricated via CO₂ laser etching of polyimide (PI) film. The platform is wirelessly connected to a portable electrochemical workstation and smartphone via Bluetooth. Laser parameters, including power and etching depth, are optimized to improve electrochemical performance. The optimized LIPG electrode exhibits significantly improved sensitivity—2.87 and 10.87-fold higher than screen-printed carbon electrode (SPCE) and glassy carbon electrode (GCE), respectively—along with excellent stability (RSD < 0.46% over 99 cycles) and a rapid 10 s response time. Quantitative detection of SM2 demonstrates good linearity (3 – 110 μM, R2 = 0.999), with low limits of detection (LOD) of 0.03 μM and quantification (LOQ) of 0.1 μM. The method is validated in spiked beef (recovery 93.34% – 103.70%) and milk (recovery 98.50% – 100.80%), confirming its practical applicability. This work is novel in systematically linking laser processing parameters to LIPG electrochemical performance and significant in demonstrating a field-deployable, cost-effective, and smartphone-enabled strategy for monitoring SM2 residues.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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