放射性同位素标记酪氨酸激酶抑制剂在肺癌诊断和治疗中的应用

IF 1.6 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-08-02 DOI:10.1007/s10967-025-10295-9

Muhammad Zahid, Hongliang Wang, Yanyan Li, Jian Zhang

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引用次数: 0

摘要

本文综述了近年来放射性标记酪氨酸激酶抑制剂（TKIs）在肺癌影像学和治疗方面的进展。具体的主题包括：TKIs的机制和历史，PET/ SPECT成像的基础，以及放射性同位素标记TKIs的技术和临床前研究。本综述的主要目的是为PET/SPECT在临床实践中使用放射性标记TKIs的安全性和可行性提供基础。图形抽象

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Radioisotope-labeled tyrosine kinase inhibitors in the diagnosis and treatment of lung cancer

This review provides a comprehensive overview of the advancements made in radiolabeled tyrosine kinase inhibitors (TKIs) for imaging and treatment of lung cancer from the past few years. Specific topics include: the mechanism and the history of TKIs, fundamentals of PET/ SPECT imaging, and the techniques as well as the preclinical studies of radioisotope labelling TKIs. The main purpose of this review is to provide the basis for the safety and viability of using radiolabeled TKIs in clinical practice with PET/SPECT.

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.