Syed Ahtzaz ul Hassan Gillani, Muhammad Usman Zahid, Zain Ali, Mohsin Zafar, Muhammad Aslam Khan, Najd Talha Bin Talha, Saeedah Musaed Almutairi, Hafiz Abdul Haseeb, Syed Ali Imran Bokhari
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Our studies find that surface capping highly influences the interaction of CeO<sub>2</sub>-NPs with biological systems as the PEGylated CeO<sub>2</sub>-NPs are completely inactive against bacterial and fungal strains compared to the highly active antimicrobial surfaces of CTAB@CeO<sub>2</sub>-NPs. Moreover, the CTAB-capped CeO<sub>2</sub>-NPs demonstrate moderate yet slightly enhanced antileishmanial and in vitro anticancer potential against MCF-7 human breast cancer cells. In contrast, PEGylated CeO<sub>2</sub>-NPs exhibit slightly improved antioxidant performance. Most importantly, both distinctly capped NPs are found to be non-toxic to human red blood cells (RBCs), demonstrating their safe nature. The study therefore concludes that surface capping plays a significant role in dictating the biological characteristics of cerium oxide nanoparticles, and the NPs can be fabricated to acquire specific biological properties.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"20 9","pages":"7293 - 7313"},"PeriodicalIF":4.3000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Distinct Biological Properties of Polyethylene Glycol (PEG) and Cetyltrimethylammonium Bromide (CTAB)-Capped Cerium Oxide Nanoparticles (CeO2-NPs)\",\"authors\":\"Syed Ahtzaz ul Hassan Gillani, Muhammad Usman Zahid, Zain Ali, Mohsin Zafar, Muhammad Aslam Khan, Najd Talha Bin Talha, Saeedah Musaed Almutairi, Hafiz Abdul Haseeb, Syed Ali Imran Bokhari\",\"doi\":\"10.1007/s11468-024-02757-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the required biological interaction can be achieved. 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The Distinct Biological Properties of Polyethylene Glycol (PEG) and Cetyltrimethylammonium Bromide (CTAB)-Capped Cerium Oxide Nanoparticles (CeO2-NPs)
The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the required biological interaction can be achieved. Herein, we have investigated and compared polyethylene glycol (PEG) and cetyltrimethylammonium bromide (CTAB)-capped cerium oxide nanoparticles (CeO2-NPs) for multiple biological properties. Both the nanoparticles (NPs) are comprehensively characterized for their physicochemical and morphological features, pH-responsive dispersion behavior, and multiple biological properties including antimicrobial, anticancer, antioxidant, and hemocompatibility. Our studies find that surface capping highly influences the interaction of CeO2-NPs with biological systems as the PEGylated CeO2-NPs are completely inactive against bacterial and fungal strains compared to the highly active antimicrobial surfaces of CTAB@CeO2-NPs. Moreover, the CTAB-capped CeO2-NPs demonstrate moderate yet slightly enhanced antileishmanial and in vitro anticancer potential against MCF-7 human breast cancer cells. In contrast, PEGylated CeO2-NPs exhibit slightly improved antioxidant performance. Most importantly, both distinctly capped NPs are found to be non-toxic to human red blood cells (RBCs), demonstrating their safe nature. The study therefore concludes that surface capping plays a significant role in dictating the biological characteristics of cerium oxide nanoparticles, and the NPs can be fabricated to acquire specific biological properties.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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