光学基因组定位（OGM）：多发性骨髓瘤细胞遗传学诊断的验证和临床应用。

IF 9.9 1区医学 Q1 HEMATOLOGY

American Journal of Hematology Pub Date : 2025-09-20 DOI:10.1002/ajh.70077

Adela Cisneros,Mar Mallo,Aleix Méndez-López,Carmen Villena,Encarnación Santafé,Jessica Tijero,Maria Abel,Neus Ruiz-Xivillé,Gladys Ibarra,Laura Abril,Anna M Sureda,Lourdes Escoda,Yolanda González-Montes,Xavier Ortín,Jose T Navarro,Albert Oriol,Francesc Solé,Isabel Granada

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引用次数: 0

摘要

与目标FISH分析相关的最终OGM评估示意图。在右边，最终的OGM结果显示是否检测到额外的改变，没有观察到改变，遗传诊断是否得到改善，或者结果是否不确定，包括FISH和OGM显示不一致而OGM未显示任何改变的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Optical Genome Mapping (OGM): Validation and Clinical Utility in the Cytogenetic Diagnosis of Multiple Myeloma.

Diagram illustrating the final OGM assessment in relation to targeted FISH analysis. On the right, the final OGM results indicate whether additional alterations were detected, no alterations were observed, genetic diagnosis was improved, or if results were inconclusive, including cases where FISH and OGM showed no concordance and OGM did not reveal any alterations.

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来源期刊

American Journal of Hematology 医学-血液学

CiteScore

15.70

自引率

3.90%

发文量

363

审稿时长

3-6 weeks

期刊介绍： The American Journal of Hematology offers extensive coverage of experimental and clinical aspects of blood diseases in humans and animal models. The journal publishes original contributions in both non-malignant and malignant hematological diseases, encompassing clinical and basic studies in areas such as hemostasis, thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports highlighting innovative therapeutic approaches for the diagnosis and treatment of hematological diseases are actively encouraged.The American Journal of Hematology features regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, as well as letters and correspondence.