精确抑制热腐毛孔为炎症治疗提供了新的机会。

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-09-19 DOI:10.1038/s41590-025-02294-5

引用次数: 0

摘要

人工智能（AI）设计的肽SK56阻断成熟的气真皮蛋白D毛孔，延缓焦亡和炎症细胞因子的释放。这减少了树突状细胞的过度活化，并防止焦亡扩散到附近的细胞。SK56还可以防止线粒体损伤，提高脓毒症小鼠的存活率，显示其作为一种新的焦亡后抗炎疗法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Precise inhibition of pyroptotic pores presents new opportunities for inflammation therapy

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Precise inhibition of pyroptotic pores presents new opportunities for inflammation therapy

The artificial intelligence (AI)-designed peptide SK56 blocks mature gasdermin D pores, delaying pyroptosis and inflammatory cytokine release. This reduces dendritic cell hyperactivation and prevents the spread of pyroptosis to nearby cells. SK56 also protects against mitochondrial damage and improves survival in septic mice, demonstrating its potential as a new post-pyroptosis, anti-inflammatory therapy.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.