Brexpiprazole:治疗阿尔茨海默病躁动的先驱药物。

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2025-09-16 eCollection Date: 2025-01-01 DOI:10.1177/25424823251379881
Ayesha Shaukat, Rumaisa Riaz, Nawal Khaliq, Zubayer Shams, Aymar Akilimali
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引用次数: 0

摘要

阿尔茨海默病带来了复杂的挑战,影响认知和行为,尤其是躁动。FDA批准了非典型抗精神病药物brexpiprazole,这是一个里程碑,代表了首个治疗阿尔茨海默病相关躁动的药物。brexpiprazole对血清素-多巴胺活性的调节在临床试验中被证明是有效的,通过CMAI评分来减少躁动。建议逐渐增加剂量,潜在的副作用包括鼻咽炎、尿路感染、头晕、嗜睡、头痛和失眠。对精神分裂症和难治性抑郁症也很有用,通过控制躁动和其他症状,提供持续治疗和潜在的幸福感增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Brexpiprazole: Pioneering medication for managing agitation in Alzheimer's disease.

Brexpiprazole: Pioneering medication for managing agitation in Alzheimer's disease.

Alzheimer's disease poses intricate challenges, affecting cognition and behavior, notably marked by agitation. The FDA's approval of brexpiprazole, an atypical antipsychotic, stands as a milestone, representing the first treatment for Alzheimer's-related agitation. brexpiprazole's modulation of serotonin-dopamine activity has proven effective in clinical trials, reducing agitation as measured by CMAI scores. Gradual dosage escalation is recommended, with potential side effects including nasopharyngitis, urinary tract infections, dizziness, somnolence, headache, and insomnia. Also useful for schizophrenia and treatment-resistant depression, providing ongoing treatment and potential well-being enhancement by managing agitation and other symptoms.

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