血液感染和浆细胞肿瘤的风险:一项基于人群的队列研究。

IF 2.6 4区 医学 Q3 IMMUNOLOGY
Adam G Stewart, Felicity Edwards, Kevin B Laupland
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引用次数: 0

摘要

背景:侵袭性感染可能是研究潜伏浆细胞肿瘤的第一个提示。本研究的目的是量化血液感染(BSI)后浆细胞肿瘤后续诊断的风险。方法:从2000年1月1日至2019年12月31日,在全州范围内进行了基于人群的监测。使用全州范围的数据库来识别在BSI诊断后1年内诊断出的浆细胞肿瘤患者。结果:90名在浆细胞肿瘤诊断前一年内患有BSI的患者和95753名没有这种恶性肿瘤的BSI患者被纳入队列。诊断浆细胞肿瘤的中位时间为BSI指数后123(31-221)天。BSI患者浆细胞肿瘤的总发病率为每年每10万人93.9例。在研究人群中,BSI的发生与浆细胞肿瘤诊断风险增加13倍相关(IRR; 12.9; 95% CI, 10.3-15.8; p)结论:BSI的存在,特别是肺炎链球菌,是少数但显著的患者隐匿性浆细胞肿瘤的标志。需要进一步的研究来确定偶发性脑损伤患者的隐匿性肿瘤疾病调查策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bloodstream Infection and Risk for Plasma Cell Neoplasms: A Population-Based Cohort Study.

Background: Invasive infection may be the first prompt to investigate the occult presence of a plasma cell neoplasm. The objective of this study was to quantify the risk for subsequent diagnosis of a plasma cell neoplasm following bloodstream infection (BSI).

Methods: Statewide population-based surveillance was conducted from January 1 2000 - December 31 2019. Statewide databases were used to identify patients with incident plasma cell neoplasms diagnosed within 1-year following a BSI diagnosis.

Results: A cohort of 90 individuals who had BSI within the year preceding diagnosis of plasma cell neoplasm and 95 753 patients with BSI without this malignancy were included. The time to diagnose a plasma cell neoplasm was a median 123 (31-221) days after index BSI. The overall incidence of plasma cell neoplasms among those with incident BSI was 93.9 per 100 000 population annually. Among the study population, development of a BSI was associated with a 13-fold increased risk for diagnosis of plasma cell neoplasm (IRR; 12.9; 95% CI, 10.3-15.8; p < 0.001). The increased risk following BSI was elevated for both sexes, with a magnitude of risk higher for females (IRR; 14.0; 95% CI, 9.8-19.4). Streptococcus pneumoniae BSI was associated with the highest risk for subsequent diagnosis of a plasma cell neoplasm (IRR 46.9; 95% CI; 26.2-77.4).

Conclusions: The presence of a BSI, particularly with S. pneumoniae, is a marker for occult plasma cell neoplasms in a small but significant number of patients. Further studies are warranted to identify occult neoplastic disease investigation strategies for patients with incident BSIs.

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来源期刊
Transplant Infectious Disease
Transplant Infectious Disease 医学-传染病学
CiteScore
5.30
自引率
7.70%
发文量
210
审稿时长
4-8 weeks
期刊介绍: Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal. Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.
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