11个先前描述的具有抗炎活性的倍半萜类化合物从担子菌中分离出来。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-09-16 DOI:10.1016/j.phytochem.2025.114678

Lan Yao , Shiyu Li , Jinxiu Zhang , Zhuang Li , Jianhua Lv

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引用次数: 0

摘要

本研究从担子菌白僵菌的大米发酵菌丝中分离得到11个未被描述的倍半萜类化合物，命名为马拉斯米ellolides A-K（1-11）。通过广泛的光谱分析，包括HR-ESI-MS， 1D和2D NMR，确定了它们的结构。化合物1-3和5-8的绝对构型是通过对比实验和计算ECD得到的。此外，我们还测试了化合物1-11对脂多糖（LPS）诱导的RAW264.7巨噬细胞一氧化氮（NO）产生的抗炎活性。化合物1 ~ 3具有显著的抗炎活性，IC50值在7.2 ~ 13.2 μM之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Eleven previously undescribed sesquiterpenoids with anti-inflammatory activity isolated from the cultures of basidiomycete Marasmiellus candidus

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Eleven previously undescribed sesquiterpenoids with anti-inflammatory activity isolated from the cultures of basidiomycete Marasmiellus candidus

In this study, eleven undescribed sesquiterpenoids, named marasmiellolides A−K (1−11), were isolated from the rice-fermented mycelia of the basidiomycete Marasmiellus candidus. Their structures were established through extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR. The absolute configurations of compounds 1−3 and 5−8 were assigned based on the comparison of the experimental and calculated ECD data. In addition, compounds 1−11 were tested for anti-inflammatory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 1−3 exhibited significant anti-inflammatory activity with IC₅₀ values ranging from 7.2 to 13.2 μM.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.