戊萜素A-D，从海洋真菌单纯青霉中提取的戊萜素型戊萜类。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-09-16 DOI:10.1016/j.phytochem.2025.114680

Yanan Yang , Xiao Han , Peiling Cai , Congcong Zhao , Anran Fu , Kun Liu , Xuli Tang , Guoqiang Li

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引用次数: 0

摘要

从海洋真菌单纯青霉中分离出4个先前未被发现的具有6/6/6/6/6个五环体系的teretonins - A-D（1-4）。戊萜类B-D（2-4）是21-非戊萜类的第一个例子，其中2和3带有一个10-羟基。通过详细的光谱数据分析、单晶x射线衍射分析（Cu Kα）、DP4+概率分析和ECD量子化学计算，确定了它们的结构。在生物实验中，化合物1、3、4对lps诱导的NO释放具有显著的抑制活性，IC50值在2.51 ~ 3.98 μM之间。

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Peniterretonins A-D, terretonin-type meroterpenoids from the marine-derived fungus Penicillium simplicissimum

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Peniterretonins A-D, terretonin-type meroterpenoids from the marine-derived fungus Penicillium simplicissimum

Four previously undescribed terretonin-type meroterpenoids, peniterretonins A–D (1–4), possessing unprecedented 6/6/6/6/6 pentacyclic systems, were isolated from the marine-derived fungus Penicillium simplicissimum. Peniterretonins B–D (2–4) represent the first examples of 21-nor-terretonin meroterpenoids, of which 2 and 3 bear a 10-hydroperoxyl group. Their structures were established by detailed analyses of the spectroscopic data, as well as by single-crystal X-ray diffraction analysis (Cu Kα), DP4+ probability analyses, and ECD quantum chemistry calculations. In the bioassays, compounds 1, 3, 4 exhibited significant inhibitory activity against LPS-induced NO release with IC₅₀ values ranging from 2.51 to 3.98 μM.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.