姑息治疗中存在和精神痛苦的迷幻辅助疗法。

4区 医学 Q3 Neuroscience
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-08-18 DOI:10.1016/bs.pbr.2025.07.002
Ana Cláudia Mesquita Garcia, Lucas Oliveira Maia
{"title":"姑息治疗中存在和精神痛苦的迷幻辅助疗法。","authors":"Ana Cláudia Mesquita Garcia, Lucas Oliveira Maia","doi":"10.1016/bs.pbr.2025.07.002","DOIUrl":null,"url":null,"abstract":"<p><p>Existential and spiritual suffering are frequently reported by individuals facing serious illnesses, particularly at the end of life, and are associated with diminished quality of life, increased psychological distress, and requests for hastened death. While Palliative Care (PC) aims to provide holistic support, existing therapeutic options often fail to adequately address the profound disruptions in meaning, connection, and dignity experienced by patients. Psychedelic-Assisted Therapies (PAT), notably those using psilocybin, have re-emerged as promising interventions capable of eliciting transformative experiences that may alleviate existential and spiritual distress. This chapter explores the potential role of PAT in PC, beginning with a historical and conceptual overview of PC and an analysis of existential and spiritual suffering in this context. It then reviews scientific evidence on the therapeutic applications of classical psychedelics, with a focus on existential and spiritual suffering. Practical, clinical, ethical, and legal considerations for the integration of PAT into PC are discussed, including the challenges of implementation and the need for spiritually and existentially informed treatment models. The chapter concludes by reinforcing the urgency of innovative and compassionate responses to existential suffering and highlighting PAT as an emerging pathway toward improving the quality of life-and death-of individuals with serious illnesses.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"107-130"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Psychedelic-assisted therapies for existential and spiritual suffering in palliative care.\",\"authors\":\"Ana Cláudia Mesquita Garcia, Lucas Oliveira Maia\",\"doi\":\"10.1016/bs.pbr.2025.07.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Existential and spiritual suffering are frequently reported by individuals facing serious illnesses, particularly at the end of life, and are associated with diminished quality of life, increased psychological distress, and requests for hastened death. While Palliative Care (PC) aims to provide holistic support, existing therapeutic options often fail to adequately address the profound disruptions in meaning, connection, and dignity experienced by patients. Psychedelic-Assisted Therapies (PAT), notably those using psilocybin, have re-emerged as promising interventions capable of eliciting transformative experiences that may alleviate existential and spiritual distress. This chapter explores the potential role of PAT in PC, beginning with a historical and conceptual overview of PC and an analysis of existential and spiritual suffering in this context. It then reviews scientific evidence on the therapeutic applications of classical psychedelics, with a focus on existential and spiritual suffering. Practical, clinical, ethical, and legal considerations for the integration of PAT into PC are discussed, including the challenges of implementation and the need for spiritually and existentially informed treatment models. The chapter concludes by reinforcing the urgency of innovative and compassionate responses to existential suffering and highlighting PAT as an emerging pathway toward improving the quality of life-and death-of individuals with serious illnesses.</p>\",\"PeriodicalId\":20598,\"journal\":{\"name\":\"Progress in brain research\",\"volume\":\"296 \",\"pages\":\"107-130\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in brain research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.pbr.2025.07.002\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in brain research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.pbr.2025.07.002","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/18 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 0

摘要

面临严重疾病的人经常报告存在和精神上的痛苦,特别是在生命结束时,并与生活质量下降、心理痛苦增加和要求加速死亡有关。虽然姑息治疗(PC)旨在提供整体支持,但现有的治疗方案往往无法充分解决患者在意义、联系和尊严方面所经历的深刻破坏。迷幻辅助疗法(PAT),特别是那些使用裸盖菇素的疗法,已经重新成为有希望的干预措施,能够引发可能减轻存在和精神痛苦的变革性体验。本章探讨PAT在PC中的潜在作用,从PC的历史和概念概述开始,并在此背景下分析存在和精神痛苦。然后,它回顾了经典迷幻药治疗应用的科学证据,重点是存在和精神痛苦。讨论了将PAT纳入PC的实践、临床、伦理和法律方面的考虑,包括实施的挑战以及对精神和存在知情治疗模式的需求。本章最后强调了对存在的痛苦作出创新和富有同情心的反应的紧迫性,并强调PAT是改善严重疾病患者生活质量和死亡质量的新兴途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychedelic-assisted therapies for existential and spiritual suffering in palliative care.

Existential and spiritual suffering are frequently reported by individuals facing serious illnesses, particularly at the end of life, and are associated with diminished quality of life, increased psychological distress, and requests for hastened death. While Palliative Care (PC) aims to provide holistic support, existing therapeutic options often fail to adequately address the profound disruptions in meaning, connection, and dignity experienced by patients. Psychedelic-Assisted Therapies (PAT), notably those using psilocybin, have re-emerged as promising interventions capable of eliciting transformative experiences that may alleviate existential and spiritual distress. This chapter explores the potential role of PAT in PC, beginning with a historical and conceptual overview of PC and an analysis of existential and spiritual suffering in this context. It then reviews scientific evidence on the therapeutic applications of classical psychedelics, with a focus on existential and spiritual suffering. Practical, clinical, ethical, and legal considerations for the integration of PAT into PC are discussed, including the challenges of implementation and the need for spiritually and existentially informed treatment models. The chapter concludes by reinforcing the urgency of innovative and compassionate responses to existential suffering and highlighting PAT as an emerging pathway toward improving the quality of life-and death-of individuals with serious illnesses.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Progress in brain research
Progress in brain research 医学-神经科学
CiteScore
5.20
自引率
0.00%
发文量
174
审稿时长
6-12 weeks
期刊介绍: Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信