基于分子分型的临床早期子宫内膜癌淋巴结转移预测模型的建立与验证。

IF 3.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Qiuyue Han, Quanhong Jiang, Jiaqi Xu, Yuan Zhang, Zhuang Li, Yong Zhao, Zhaoyang Zhang, Ziyuan Yang, Helgi B Schiöth, Yawen Zhang, Lingliya Tang, Shuaixin Wang, Beihua Kong, Ruifen Dong
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引用次数: 0

摘要

目的:建立结合分子分型和临床特征的基于机器学习的术前预测早期子宫内膜癌(EC)患者淋巴结转移(LNM)模型并进行外部验证。方法:对山东大学齐鲁医院465例临床早期EC患者进行回顾性研究。使用基于癌症基因组图谱的方法将肿瘤分类为分子亚型。最小绝对收缩和选择算子回归确定了五个术前预测因素:分子分型(CN-H vs.非CN-H)、组织学亚型、肌层浸润深度、中性粒细胞与淋巴细胞比例和CA125水平。评估多种机器学习算法,并根据最佳判别和临床适用性选择逻辑回归(LR)。使用曲线下面积(AUC)、校准图和决策曲线分析(DCA)评估模型性能。开发了一种用于临床的基于网络的线图。结果:LR模型具有很好的判别性,训练队列的auc为0.843,测试队列的auc为0.809。CN-H亚型与LNM风险增加显著相关。该模型实现了有效的风险分层和校准曲线,DCA证实了模型的准确性和临床实用性。结论:通过整合分子和术前临床特征,该模型为早期EC提供了准确的LNM风险分层。它支持临床决策,并已作为一个用户友好的在线工具实施。进一步的前瞻性多中心验证是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and validation of a prediction model for lymph node metastasis based on molecular typing in clinically early-stage endometrial carcinoma.

Objective: To develop and externally validate a machine learning-based preoperative model integrating molecular typing and clinical features to predict lymph node metastasis (LNM) in patients with early-stage endometrial carcinoma (EC).

Methods: This retrospective study included 465 patients with clinically early-stage EC treated at Qilu Hospital of Shandong University. Tumors were classified into molecular subtypes using The Cancer Genome Atlas-based methods. Least Absolute Shrinkage and Selection Operator regression identified five preoperative predictors: molecular typing (CN-H vs. non-CN-H), histological subtype, depth of myometrial invasion, neutrophil-to-lymphocyte ratio, and CA125 levels. Multiple machine learning algorithms were evaluated, and logistic regression (LR) was selected based on optimal discrimination and clinical applicability. Model performance was assessed using area under the curve (AUC), calibration plots, and decision curve analysis (DCA). A web-based nomogram was developed for clinical use.

Results: The LR model demonstrated excellent discrimination, with AUCs of 0.843 in the training cohort and 0.809 in the testing cohort. The CN-H subtype was significantly associated with increased LNM risk. The model enabled effective risk stratification and calibration curves and DCA confirmed the model's accuracy and clinical utility.

Conclusion: By integrating molecular and preoperative clinical features, this model offers accurate LNM risk stratification for early-stage EC. It supports clinical decision-making and has been implemented as a user-friendly online tool. Further prospective multicenter validation is warranted.

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来源期刊
Journal of Gynecologic Oncology
Journal of Gynecologic Oncology ONCOLOGY-OBSTETRICS & GYNECOLOGY
CiteScore
6.00
自引率
2.60%
发文量
84
审稿时长
>12 weeks
期刊介绍: The Journal of Gynecologic Oncology (JGO) is an official publication of the Asian Society of Gynecologic Oncology. Abbreviated title is ''J Gynecol Oncol''. It was launched in 1990. The JGO''s aim is to publish the highest quality manuscripts dedicated to the advancement of care of the patients with gynecologic cancer. It is an international peer-reviewed periodical journal that is published bimonthly (January, March, May, July, September, and November). Supplement numbers are at times published. The journal publishes editorials, original and review articles, correspondence, book review, etc.
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