基于Friedewald公式计算的过量甘油三酯可能是生产大量极低密度脂蛋白的替代标记物,这是PROUD48研究的事后分析。

IF 2.8 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Tsutomu Hirano, Yasutaka Takeda, Ichiro Sakuma, Shinya Hiramitsu, Mizuho Okada, Shinichiro Ueda, Masaru Sakurai
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引用次数: 0

摘要

目的:大极低密度脂蛋白1 (VLDL1)的过量产生是代谢性血脂异常的中心异常。根据Friedewald方程,过量甘油三酯(Ex-TG)被认为是富含tg的VLDL的标志,但Ex-TG是否反映了较大的VLDL颗粒仍不确定。方法:我们对PROUD48研究进行了回顾性亚分析,该研究比较了帕马菲特和omega-3脂肪酸(FAs)对载脂蛋白B48的影响,并提供了VLDL亚组分的数据。接受他汀类药物治疗的高脂血症患者用培马哌特(n = 56)或omega-3FAs (n = 56)治疗16周。采用高效液相色谱法分离VLDL亚组分:大(L)、中(M)、小(S)。前TG计算为血浆TG减去5 ×计算的vldl -胆固醇(C)。计算的VLDL=总c减去直接测量的LDL-C减去HDL-C。结果:pemafbrate和omega-3FAs分别降低了血浆TG水平42%和27%;然而,只有omega-3脂肪酸能显著降低Ex-TG。Ex-TG与L-VLDL-TG、%L-VLDL-TG、(L-M+S)-VLDL-TG、L-VLDL-TG/C呈正相关,与较小的vldl、apoB48无正相关。与Ex-TG相比,TG与l - vldl相关参数的相关性更强,但也与较小的vldl和apoB48呈正相关。即使在使用降脂剂检查Ex-TG、TG或apoB48变化与VLDL亚组分相应变化之间的关系时,这些相关模式仍然保持一致。结论:前-TG的行为与先前的动力学研究一致,表明omega-3FAs主要抑制VLDL1的产生,而贝特酸盐则促进TG的去除,这表明前-TG可以作为VLDL1过量产生的替代标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Calculated Excess-Triglyceride Based on the Friedewald Formula is a Possible Surrogate Marker for the Production of Large Very-Low Density Lipoprotein, A Post-Hoc Analysis of the PROUD48 Study.

Aim: Overproduction of large very low-density lipoprotein1 (VLDL1) is a central abnormality in metabolic dyslipidemia. Excess-triglycerides (Ex-TG), based on the Friedewald equation, is considered to be a marker for TG-rich VLDL, but it remains uncertain whether Ex-TG reflects large VLDL particles.

Methods: We conducted a retrospective sub-analysis of the PROUD48 study, which compared the effects of pemafibrate and omega-3 fatty acids (FAs) on apolipoprotein B48, with data available on VLDL subfractions. Hyperlipidemic patients on statins were treated with pemafibrate (n = 56) or omega-3FAs (n = 56) for 16 weeks. VLDL subfractions: large (L), middle (M), and small (S) were separated using high-performance liquid chromatography. Ex-TG was calculated as plasma TG minus 5 x calculated VLDL-cholesterol (C).Calculated VLDL=total-C minus directly measured LDL-C minus HDL-C.

Results: Pemafibrate and omega-3FAs reduced plasma TG levels by 42% and 27%, respectively; however, a marked reduction in Ex-TG was observed only with omega-3 FAs. Ex-TG was positively correlated with L-VLDL-TG, %L-VLDL-TG, (L-M+S)-VLDL-TG, and L-VLDL-TG/C, while it showed no positive correlation with smaller VLDLs and apoB48. TG exhibited stronger correlations with L-VLDL-related parameters than Ex-TG, but was also positively associated with smaller VLDLs and apoB48. These correlation patterns remained consistent even when examining the relationship between changes in Ex-TG, TG, or apoB48 and corresponding changes in VLDL subfractions using lipid-lowering agents.

Conclusions: The behavior of Ex-TG appears consistent with previous kinetic studies showing that omega-3FAs primarily suppress VLDL1 production, whereas fibrates promote TG removal, suggesting that Ex-TG serves as a surrogate marker for VLDL1 overproduction.

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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
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