细胞膜上的TOR信号。

IF 3 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology

FEBS Letters Pub Date : 2025-09-19 DOI:10.1002/1873-3468.70171

Robbie Loewith, Lucas Tafur

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引用次数: 0

摘要

雷帕霉素靶蛋白（TOR）是一种高度保守的蛋白激酶，通过TORC1和TORC2两种不同的复合物调节细胞生长和代谢。每个复合物调节不同的下游目标；然而，两者都在脂质膜上被激活和调节。在本研究中，我们将对TOR复合物的结构生物学及其调控的分子机制进行修订，强调脂质膜对其功能的重要性。

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TOR signaling on membranes.

The Target of Rapamycin (TOR) is a highly conserved protein kinase that regulates cell growth and metabolism through two distinct complexes, TORC1 and TORC2. Each complex regulates different downstream targets; however, both are activated and regulated on lipid membranes. In this Perspective, we will revise the structural biology of TOR complexes and the molecular mechanisms governing their regulation, highlighting the importance of lipid membranes for their function.

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.