碳青霉烯耐药铜绿假单胞菌的全球威胁流行。

IF 2.2 4区 医学 Q3 INFECTIOUS DISEASES
Mohammad Hossein Ahmadi, Zeinab Fagheei Aghmiyuni, Shahriar Bakhti
{"title":"碳青霉烯耐药铜绿假单胞菌的全球威胁流行。","authors":"Mohammad Hossein Ahmadi, Zeinab Fagheei Aghmiyuni, Shahriar Bakhti","doi":"10.1017/S0950268825100332","DOIUrl":null,"url":null,"abstract":"<p><p>β-Lactam/β-lactamase inhibitor combinations and carbapenems are the first-line treatments for multidrug-resistant <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) infections. However, carbapenem resistance is increasing globally at an alarming rate, which is especially concerning given the pivotal role of these agents. This study comprehensively evaluated the global distribution of carbapenem resistance in clinical <i>P. aeruginosa</i> isolates. The keywords including '<i>Pseudomonas', P. aeruginosa'</i>, '<i>P. aeruginosa'</i>, 'resistance', 'susceptibility', 'carbapenem antibiotics', 'carbapenems', 'imipenem', 'meropenem', 'ertapenem', 'doripenem', as well as 'prevalence' and 'incidence' were searched in electronic databases as the appropriate keywords. After screening, 160 studies were excluded, with 87 eligible studies from diverse geographic regions retained for final analysis. A comprehensive meta-analysis was then conducted on the data collected. The mean resistance rates (95% CI) were 33.3% (imipenem), 23.3% (meropenem), 60.9% (ertapenem), and 36.7% (doripenem). The time trend analysis showed that the resistance to meropenem has increased from the year 1997 to 2023. Meta-analysis showed substantial heterogeneity (I<sup>2</sup> = 92%, p < 0.05) but no significant publication bias by Egger's or Begg's test. Global carbapenem resistance is alarmingly high in clinical <i>P. aeruginosa</i> isolates. The increasing prevalence of carbapenem-resistant <i>P. aeruginosa</i> is a major global health threat requiring urgent action through new antimicrobials and improved antibiotic stewardship to protect these last-line drugs.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e114"},"PeriodicalIF":2.2000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Worldwide threatening prevalence of carbapenem-resistant <i>Pseudomonas aeruginosa</i>.\",\"authors\":\"Mohammad Hossein Ahmadi, Zeinab Fagheei Aghmiyuni, Shahriar Bakhti\",\"doi\":\"10.1017/S0950268825100332\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>β-Lactam/β-lactamase inhibitor combinations and carbapenems are the first-line treatments for multidrug-resistant <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) infections. However, carbapenem resistance is increasing globally at an alarming rate, which is especially concerning given the pivotal role of these agents. This study comprehensively evaluated the global distribution of carbapenem resistance in clinical <i>P. aeruginosa</i> isolates. The keywords including '<i>Pseudomonas', P. aeruginosa'</i>, '<i>P. aeruginosa'</i>, 'resistance', 'susceptibility', 'carbapenem antibiotics', 'carbapenems', 'imipenem', 'meropenem', 'ertapenem', 'doripenem', as well as 'prevalence' and 'incidence' were searched in electronic databases as the appropriate keywords. After screening, 160 studies were excluded, with 87 eligible studies from diverse geographic regions retained for final analysis. A comprehensive meta-analysis was then conducted on the data collected. The mean resistance rates (95% CI) were 33.3% (imipenem), 23.3% (meropenem), 60.9% (ertapenem), and 36.7% (doripenem). The time trend analysis showed that the resistance to meropenem has increased from the year 1997 to 2023. Meta-analysis showed substantial heterogeneity (I<sup>2</sup> = 92%, p < 0.05) but no significant publication bias by Egger's or Begg's test. Global carbapenem resistance is alarmingly high in clinical <i>P. aeruginosa</i> isolates. The increasing prevalence of carbapenem-resistant <i>P. aeruginosa</i> is a major global health threat requiring urgent action through new antimicrobials and improved antibiotic stewardship to protect these last-line drugs.</p>\",\"PeriodicalId\":11721,\"journal\":{\"name\":\"Epidemiology and Infection\",\"volume\":\" \",\"pages\":\"e114\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiology and Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S0950268825100332\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology and Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0950268825100332","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

β-内酰胺/β-内酰胺酶抑制剂联合和碳青霉烯类药物是耐多药铜绿假单胞菌感染的一线治疗方法。然而,碳青霉烯耐药性正在全球范围内以惊人的速度增加,鉴于这些药物的关键作用,这尤其令人担忧。本研究综合评价了铜绿假单胞菌临床分离株碳青霉烯类耐药的全球分布。在电子数据库中检索“假单胞菌”、“铜绿假单胞菌”、“铜绿假单胞菌”、“耐药”、“敏感性”、“碳青霉烯类抗生素”、“碳青霉烯类抗生素”、“亚胺培南”、“美罗培南”、“厄他培南”、“多利培南”以及“患病率”和“发病率”等关键词。筛选后,160项研究被排除,来自不同地理区域的87项符合条件的研究被保留用于最终分析。然后对收集的数据进行全面的荟萃分析。平均耐药率(95% CI)分别为:亚胺培南33.3%、美罗培南23.3%、厄他培南60.9%、多利培南36.7%。时间趋势分析表明,1997 - 2023年对美罗培南的耐药性呈上升趋势。荟萃分析显示了显著的异质性(I2 = 92%, p铜绿假单胞菌分离株)。耐碳青霉烯P.铜绿假单胞菌的日益流行是一个主要的全球健康威胁,需要采取紧急行动,开发新的抗微生物药物并改进抗生素管理,以保护这些最后一线药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Worldwide threatening prevalence of carbapenem-resistant Pseudomonas aeruginosa.

β-Lactam/β-lactamase inhibitor combinations and carbapenems are the first-line treatments for multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infections. However, carbapenem resistance is increasing globally at an alarming rate, which is especially concerning given the pivotal role of these agents. This study comprehensively evaluated the global distribution of carbapenem resistance in clinical P. aeruginosa isolates. The keywords including 'Pseudomonas', P. aeruginosa', 'P. aeruginosa', 'resistance', 'susceptibility', 'carbapenem antibiotics', 'carbapenems', 'imipenem', 'meropenem', 'ertapenem', 'doripenem', as well as 'prevalence' and 'incidence' were searched in electronic databases as the appropriate keywords. After screening, 160 studies were excluded, with 87 eligible studies from diverse geographic regions retained for final analysis. A comprehensive meta-analysis was then conducted on the data collected. The mean resistance rates (95% CI) were 33.3% (imipenem), 23.3% (meropenem), 60.9% (ertapenem), and 36.7% (doripenem). The time trend analysis showed that the resistance to meropenem has increased from the year 1997 to 2023. Meta-analysis showed substantial heterogeneity (I2 = 92%, p < 0.05) but no significant publication bias by Egger's or Begg's test. Global carbapenem resistance is alarmingly high in clinical P. aeruginosa isolates. The increasing prevalence of carbapenem-resistant P. aeruginosa is a major global health threat requiring urgent action through new antimicrobials and improved antibiotic stewardship to protect these last-line drugs.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信