Kelly M. Shaffer PhD, Katharine E. Daniel PhD, Kara P. Wiseman PhD, Lee M. Ritterband PhD, David C. Mohr PhD, Wendy Cohn PhD, Shayna L. Showalter MD, Philip I. Chow PhD
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This secondary analysis examined the prospective association between breast cancer survivors' sleep quality and sexual satisfaction.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Distressed breast cancer survivors (<i>N</i> = 313; mean age, 52 years [range: 27–77 years]; 84% non-Hispanic White) reported sleep quality (Pittsburgh Sleep Quality Index) and sexual satisfaction (Patient Reported Outcomes Measurement Information System Satisfaction With Sex Life Scale) at baseline, 8 weeks, 6 months, and 12 months in a randomized clinical trial of an application-based distress intervention. Parallel-process latent growth modeling was used to test associations between trajectories of these domains, adjusting for age and partner status.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Most survivors (77%) reported clinically significant impairments in both sleep quality and sexual satisfaction at one or more timepoints. Model fit was strong (χ<sup>2</sup>[29] = 24.47; <i>p</i> = .71; comparative fit index = 1.00; standardized root mean square residual = .025), with no moderation by intervention condition. Both sleep quality (<i>p</i> < .001) and sexual satisfaction (<i>p</i> = .004) improved over time, with greater improvements observed among participants with worse initial scores (<i>p</i> = .01 for both associations). Sleep quality and sexual satisfaction were positively associated at baseline (<i>p</i> < .001), but initial levels in one domain did not predict changes in the other, and their trajectories were not significantly related.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Poor sleep and low sexual satisfaction commonly co-occur among distressed breast cancer survivors and are cross-sectionally related. However, changes in these domains occurred independently over time, highlighting the importance of evaluating both concerns and providing domain-specific survivorship care.</p>\n </section>\n </div>","PeriodicalId":138,"journal":{"name":"Cancer","volume":"131 19","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445633/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prospective associations between sleep quality and sexual satisfaction in distressed breast cancer survivors: Secondary analysis from the Apps Reaching Cancer Survivors randomized trial\",\"authors\":\"Kelly M. Shaffer PhD, Katharine E. Daniel PhD, Kara P. Wiseman PhD, Lee M. Ritterband PhD, David C. Mohr PhD, Wendy Cohn PhD, Shayna L. Showalter MD, Philip I. 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引用次数: 0
摘要
背景：全球每20名女性中就有1人将在其一生中被诊断患有乳腺癌，并且在治疗后面临睡眠质量差和性功能障碍的风险增加。关于这些普遍存在的生存问题如何随着时间的推移相互影响的证据有限。这项二次分析研究了乳腺癌幸存者的睡眠质量和性满意度之间的潜在联系。方法：在一项基于应用的痛苦干预的随机临床试验中，痛苦的乳腺癌幸存者（N = 313，平均年龄52岁[范围：27-77岁]；84%非西班牙裔白人）报告了基线、8周、6个月和12个月的睡眠质量（匹兹堡睡眠质量指数）和性满意度（患者报告的结果测量信息系统满意度量表）。平行过程潜在增长模型用于测试这些领域轨迹之间的关联，调整年龄和伴侣状态。结果：大多数幸存者（77%）在一个或多个时间点报告了临床显著的睡眠质量和性满意度受损。模型拟合较强（χ2[29] = 24.47; p = 0.71；比较拟合指数= 1.00；标准化均方根残差= 0.025），不受干预条件的影响。结论：睡眠质量差和性满意度低通常同时发生在痛苦的乳腺癌幸存者中，并且具有横断面相关性。然而，随着时间的推移，这些领域的变化是独立发生的，这突出了评估关注点和提供特定于领域的生存护理的重要性。
Prospective associations between sleep quality and sexual satisfaction in distressed breast cancer survivors: Secondary analysis from the Apps Reaching Cancer Survivors randomized trial
Background
One in 20 women globally will be diagnosed with breast cancer in her lifetime and face increased risk for poor sleep quality and sexual functioning after treatment. Limited evidence exists on how these prevalent survivorship concerns influence each other over time. This secondary analysis examined the prospective association between breast cancer survivors' sleep quality and sexual satisfaction.
Methods
Distressed breast cancer survivors (N = 313; mean age, 52 years [range: 27–77 years]; 84% non-Hispanic White) reported sleep quality (Pittsburgh Sleep Quality Index) and sexual satisfaction (Patient Reported Outcomes Measurement Information System Satisfaction With Sex Life Scale) at baseline, 8 weeks, 6 months, and 12 months in a randomized clinical trial of an application-based distress intervention. Parallel-process latent growth modeling was used to test associations between trajectories of these domains, adjusting for age and partner status.
Results
Most survivors (77%) reported clinically significant impairments in both sleep quality and sexual satisfaction at one or more timepoints. Model fit was strong (χ2[29] = 24.47; p = .71; comparative fit index = 1.00; standardized root mean square residual = .025), with no moderation by intervention condition. Both sleep quality (p < .001) and sexual satisfaction (p = .004) improved over time, with greater improvements observed among participants with worse initial scores (p = .01 for both associations). Sleep quality and sexual satisfaction were positively associated at baseline (p < .001), but initial levels in one domain did not predict changes in the other, and their trajectories were not significantly related.
Conclusions
Poor sleep and low sexual satisfaction commonly co-occur among distressed breast cancer survivors and are cross-sectionally related. However, changes in these domains occurred independently over time, highlighting the importance of evaluating both concerns and providing domain-specific survivorship care.
期刊介绍：
The CANCER site is a full-text, electronic implementation of CANCER, an Interdisciplinary International Journal of the American Cancer Society, and CANCER CYTOPATHOLOGY, a Journal of the American Cancer Society.
CANCER publishes interdisciplinary oncologic information according to, but not limited to, the following disease sites and disciplines: blood/bone marrow; breast disease; endocrine disorders; epidemiology; gastrointestinal tract; genitourinary disease; gynecologic oncology; head and neck disease; hepatobiliary tract; integrated medicine; lung disease; medical oncology; neuro-oncology; pathology radiation oncology; translational research
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