Martin Perez-Estebanez , Fabiola Olmo-Alonso , Natalia Baran , Martin Jönsson-Niedziółka , Magdalena Z. Wiloch
{"title":"抗阿尔茨海默病潜在药物TDMQ20的光谱电化学研究——第二部分- cu络合物。","authors":"Martin Perez-Estebanez , Fabiola Olmo-Alonso , Natalia Baran , Martin Jönsson-Niedziółka , Magdalena Z. Wiloch","doi":"10.1016/j.bioelechem.2025.109115","DOIUrl":null,"url":null,"abstract":"<div><div>Alzheimer's Disease (AD) has been associated with the overproduction reactive radicals through the catalytic effect of β-amyloid peptide Cu(II) complexes. In this article, we performed electrochemical characterisation of copper complexed with TDMQ20, which has been suggested as a potential drug against AD, using electrochemistry and spectroelectrochemistry (SEC). Based on voltammetry, we showed that oxidation as well as reduction processes of Cu(II)-TDMQ20 are pH-sensitive. Simulations of the CVs allowed us to estimate the kinetic parameters of the initial quasi-reversible oxidation of Cu(II) and the subsequent internal electron transfer to the Cu(III) ion from the TDMQ20 ligand (k<sub>0</sub> ≈ 18 s<sup>−1</sup>). The electrochemical mechanism of oxidation/reduction of Cu(II)-TDM20 complex was also studied using UV-VIS absorption spectroelectrochemistry (UV-VIS SEC). UV-VIS SEC measurements showed that after oxidation of the ligand through the reduction of the Cu(III), the Cu remains complexed with the TDMQ20, but the electrochemical properties of the complex are changed. Our findings contribute to a broader understanding of the redox activity of the Cu(II)-TDMQ20 complex at physiological pH, which is a crucial aspect in evaluating the potential clinical utility of this compound.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"168 ","pages":"Article 109115"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer's disease - part 2 - Cu-complexes\",\"authors\":\"Martin Perez-Estebanez , Fabiola Olmo-Alonso , Natalia Baran , Martin Jönsson-Niedziółka , Magdalena Z. Wiloch\",\"doi\":\"10.1016/j.bioelechem.2025.109115\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Alzheimer's Disease (AD) has been associated with the overproduction reactive radicals through the catalytic effect of β-amyloid peptide Cu(II) complexes. In this article, we performed electrochemical characterisation of copper complexed with TDMQ20, which has been suggested as a potential drug against AD, using electrochemistry and spectroelectrochemistry (SEC). Based on voltammetry, we showed that oxidation as well as reduction processes of Cu(II)-TDMQ20 are pH-sensitive. Simulations of the CVs allowed us to estimate the kinetic parameters of the initial quasi-reversible oxidation of Cu(II) and the subsequent internal electron transfer to the Cu(III) ion from the TDMQ20 ligand (k<sub>0</sub> ≈ 18 s<sup>−1</sup>). The electrochemical mechanism of oxidation/reduction of Cu(II)-TDM20 complex was also studied using UV-VIS absorption spectroelectrochemistry (UV-VIS SEC). UV-VIS SEC measurements showed that after oxidation of the ligand through the reduction of the Cu(III), the Cu remains complexed with the TDMQ20, but the electrochemical properties of the complex are changed. Our findings contribute to a broader understanding of the redox activity of the Cu(II)-TDMQ20 complex at physiological pH, which is a crucial aspect in evaluating the potential clinical utility of this compound.</div></div>\",\"PeriodicalId\":252,\"journal\":{\"name\":\"Bioelectrochemistry\",\"volume\":\"168 \",\"pages\":\"Article 109115\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioelectrochemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S156753942500218X\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectrochemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156753942500218X","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer's disease - part 2 - Cu-complexes
Alzheimer's Disease (AD) has been associated with the overproduction reactive radicals through the catalytic effect of β-amyloid peptide Cu(II) complexes. In this article, we performed electrochemical characterisation of copper complexed with TDMQ20, which has been suggested as a potential drug against AD, using electrochemistry and spectroelectrochemistry (SEC). Based on voltammetry, we showed that oxidation as well as reduction processes of Cu(II)-TDMQ20 are pH-sensitive. Simulations of the CVs allowed us to estimate the kinetic parameters of the initial quasi-reversible oxidation of Cu(II) and the subsequent internal electron transfer to the Cu(III) ion from the TDMQ20 ligand (k0 ≈ 18 s−1). The electrochemical mechanism of oxidation/reduction of Cu(II)-TDM20 complex was also studied using UV-VIS absorption spectroelectrochemistry (UV-VIS SEC). UV-VIS SEC measurements showed that after oxidation of the ligand through the reduction of the Cu(III), the Cu remains complexed with the TDMQ20, but the electrochemical properties of the complex are changed. Our findings contribute to a broader understanding of the redox activity of the Cu(II)-TDMQ20 complex at physiological pH, which is a crucial aspect in evaluating the potential clinical utility of this compound.
期刊介绍:
An International Journal Devoted to Electrochemical Aspects of Biology and Biological Aspects of Electrochemistry
Bioelectrochemistry is an international journal devoted to electrochemical principles in biology and biological aspects of electrochemistry. It publishes experimental and theoretical papers dealing with the electrochemical aspects of:
• Electrified interfaces (electric double layers, adsorption, electron transfer, protein electrochemistry, basic principles of biosensors, biosensor interfaces and bio-nanosensor design and construction.
• Electric and magnetic field effects (field-dependent processes, field interactions with molecules, intramolecular field effects, sensory systems for electric and magnetic fields, molecular and cellular mechanisms)
• Bioenergetics and signal transduction (energy conversion, photosynthetic and visual membranes)
• Biomembranes and model membranes (thermodynamics and mechanics, membrane transport, electroporation, fusion and insertion)
• Electrochemical applications in medicine and biotechnology (drug delivery and gene transfer to cells and tissues, iontophoresis, skin electroporation, injury and repair).
• Organization and use of arrays in-vitro and in-vivo, including as part of feedback control.
• Electrochemical interrogation of biofilms as generated by microorganisms and tissue reaction associated with medical implants.