Maria Franquesa-Mullerat, Alejandra O. Morcillo-Nieto, José Enrique Arriola-Infante, Sara E. Zsadanyi, Lídia Vaqué-Alcázar, Mateus Rozalem-Aranha, Javier Arranz, Íñigo Rodríguez-Baz, Lucia Maure-Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Sandra Giménez, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona-Iragui, Juan Fortea, Alexandre Bejanin
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Zsadanyi, Lídia Vaqué-Alcázar, Mateus Rozalem-Aranha, Javier Arranz, Íñigo Rodríguez-Baz, Lucia Maure-Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Sandra Giménez, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona-Iragui, Juan Fortea, Alexandre Bejanin","doi":"10.1002/alz.70581","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>We assessed pseudo-continuous arterial spin labeling (pCASL) sensitivity to detect changes in cerebral blood flow (CBF) in adults with Down syndrome (DS) along the Alzheimer's disease (AD) continuum and explored the similarity with sporadic AD (sAD) hypoperfusion profile.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Fifty-one euploid cognitively unimpaired individuals, 54 adults with DS (34.54% symptomatic for AD), and 25 sAD patients underwent 3T magnetic resonance imaging. pCASL images were preprocessed using ASLprep. Analyses explored, globally and regionally, the effects of demographic variables, clinical stages, and AD biomarkers.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Age and sex differently impacted CBF in euploids versus the DS population. Asymptomatic DS showed temporo-parietal hypoperfusion, extending into frontal areas in symptomatic cases. This pattern closely resembled sAD's pattern and correlated with AD biomarkers.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Adults with DS present CBF changes before symptom onset, primarily affecting posterior regions as in sAD. pCASL is a sensitive imaging modality that captures early AD-related functional abnormalities in DS.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Perfusion is negatively affected by age and correlates with Alzheimer's disease (AD) biomarkers in Down syndrome (DS).</li>\n \n <li>Hypoperfusion in DS was observed even before the onset of the AD clinical symptoms.</li>\n \n <li>The pattern of hypoperfusion in the DS population resembles the one observed in the sporadic AD population.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70581","citationCount":"0","resultStr":"{\"title\":\"Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum\",\"authors\":\"Maria Franquesa-Mullerat, Alejandra O. 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Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum
INTRODUCTION
We assessed pseudo-continuous arterial spin labeling (pCASL) sensitivity to detect changes in cerebral blood flow (CBF) in adults with Down syndrome (DS) along the Alzheimer's disease (AD) continuum and explored the similarity with sporadic AD (sAD) hypoperfusion profile.
METHODS
Fifty-one euploid cognitively unimpaired individuals, 54 adults with DS (34.54% symptomatic for AD), and 25 sAD patients underwent 3T magnetic resonance imaging. pCASL images were preprocessed using ASLprep. Analyses explored, globally and regionally, the effects of demographic variables, clinical stages, and AD biomarkers.
RESULTS
Age and sex differently impacted CBF in euploids versus the DS population. Asymptomatic DS showed temporo-parietal hypoperfusion, extending into frontal areas in symptomatic cases. This pattern closely resembled sAD's pattern and correlated with AD biomarkers.
DISCUSSION
Adults with DS present CBF changes before symptom onset, primarily affecting posterior regions as in sAD. pCASL is a sensitive imaging modality that captures early AD-related functional abnormalities in DS.
Highlights
Perfusion is negatively affected by age and correlates with Alzheimer's disease (AD) biomarkers in Down syndrome (DS).
Hypoperfusion in DS was observed even before the onset of the AD clinical symptoms.
The pattern of hypoperfusion in the DS population resembles the one observed in the sporadic AD population.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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