微流控器官芯片装置：一个独特的研究植入和胎盘的平台。

IF 7 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Fertility and sterility Pub Date : 2025-09-16 DOI:10.1016/j.fertnstert.2025.09.020

Sneha Mani,Se-Jeong Kim,Rosemary Flock,Dongeun Huh,Monica Mainigi

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引用次数: 0

摘要

早期胎盘关键过程的中断与几种妊娠障碍有关，导致全球高发病率和死亡率。然而，我们无法检测或改变这些疾病的病程，因为其发展的基本机制仍未完全描述。这源于无法从伦理上在体内研究这些过程，以及缺乏以生理相关方式在体外模拟早期胎盘的技术。

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Microfluidic organ-on-chip device: a unique platform for investigating implantation and placentation.

Disruption of critical processes during early placentation is associated with several pregnancy disorders, leading to high rates of morbidity and mortality globally. However, we are unable to detect or modify the course of these disorders because the fundamental mechanisms underlying their development remain incompletely described. This stems from an inability to ethically study these processes in vivo and a lack of technology to model early placentation in vitro in a physiologically relevant manner.

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来源期刊

Fertility and sterility 医学-妇产科学

CiteScore

11.30

自引率

6.00%

发文量

1446

审稿时长

31 days

期刊介绍： Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.