遵守修订的美国心脏协会心血管健康标准可降低地中海1型糖尿病患者的动脉粥样硬化负担

IF 6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Camila Milad, Clara Viñals, Verónica Perea, Tonet Serés-Noriega, Antonio-Jesús Blanco-Carrasco, Irene Vinagre, Maria Claro, Clara Solà, Alex Mesa, Dennisse Ayala, Ignacio Conget, Marga Giménez, Antonio J. Amor
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引用次数: 0

摘要

目的:心血管危险因素(CVRF)管理和健康的生活方式可以预防心血管疾病(CVD),尽管它们对1型糖尿病(T1D)的影响尚未得到充分探讨。本研究旨在探讨该人群中健康生活方式参数与临床前动脉粥样硬化之间的关系。材料和方法:横断面研究在没有确定CVD的T1D患者中,满足以下条件之一:≥40岁,糖尿病肾病,或T1D持续时间≥10年并伴有另一种CVRF。我们使用了美国心脏协会“生活简单七分”(AHA-LSS)评分系统的修改版,测量了7个变量(体重指数、吸烟、体育活动、地中海饮食、ldl -胆固醇、血压和HbA1c),评分范围为0-13分(得分越高,CVRF概况越好)。使用颈动脉超声评估斑块的存在。将患者分为低(AHA-LSS≤5)、中(AHA-LSS 6-7)和高(AHA-LSS≥8)三组。采用logistic回归模型评估AHA评分与动脉粥样硬化之间的关系。结果:纳入n = 518例患者(55%为女性,年龄48±11岁,T1D病程27±11年,HbA1c 7.49±0.90%,AHA-LLS 6[5-8])。AHA-LSS评分与不同的cvrf和斑块负担呈负相关(p)。结论:全面控制cvrf和健康的生活方式与T1D患者临床前动脉粥样硬化患病率降低相关。这些发现强调了在这一人群中解决非血糖因素以改善心血管健康的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adherence to Modified American Heart Association Cardiovascular Health Standards Is Associated With Lower Atherosclerotic Burden in Mediterranean Individuals With Type 1 Diabetes

Objectives

Cardiovascular risk factor (CVRF) management and healthy lifestyles protect against cardiovascular disease (CVD), although their impact in type 1 diabetes (T1D) is underexplored. This study aimed to examine the relationship between healthy lifestyle parameters and preclinical atherosclerosis in this population.

Materials and Methods

Cross-sectional study in individuals with T1D without established CVD, meeting one of the following: ≥ 40 years-old, diabetic kidney disease, or ≥ 10 years duration of T1D with another CVRF. We used a modification of the American Heart Association ‘Life's Simple Seven’ (AHA-LSS) scoring system, measuring 7 variables (body mass index, smoking, physical activity, Mediterranean diet, LDL-cholesterol, blood pressure, and HbA1c) scoring ranging 0–13 points (higher score, better CVRF profile). Presence of plaques was assessed using carotid ultrasound. Patients were categorised into low (AHA-LSS ≤ 5), medium (AHA-LSS 6–7) and high (AHA-LSS ≥ 8) tertiles. Associations between AHA score and atherosclerosis were assessed using logistic regression models.

Results

We included n = 518 individuals (55% women, age 48 ± 11 years, T1D duration 27 ± 11 years, HbA1c 7.49 ± 0.90%, AHA-LLS 6 [5–8]). An inverse relationship was observed between AHA-LSS score and different CVRFs and plaque burden (p < 0.05 for all). This inverse relationship persisted after adjusting for classical and specific-T1D CVRFs not included in the score, both for plaque presence (OR 0.37 [0.20–0.70]) and ≥ 2 plaques (OR 0.30 [0.13–0.68]; p < 0.05).

Conclusions

Holistic control of CVRFs and healthy lifestyles are associated with lower preclinical atherosclerosis prevalence in individuals with T1D. These findings highlight the need to address non-glycaemic factors in this population to improve cardiovascular health.

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来源期刊
Diabetes/Metabolism Research and Reviews
Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢
CiteScore
17.20
自引率
2.50%
发文量
84
审稿时长
4-8 weeks
期刊介绍: Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.
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