AARS1/2：蛋白质翻译和代谢免疫调节的双重功能。

Q3 Medicine

遗传 Pub Date : 2025-09-01 DOI:10.16288/j.yczz.25-034

Zong-Wang Zhang, Jing-Wei Xiong

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引用次数: 0

摘要

高度精确的蛋白质合成调节对生物体内平衡和功能至关重要。Alanyl-tRNA合成酶（AARS1/2）在这个过程中起着至关重要的作用。AARS1/2是一类在细胞内合成丙烯酰trna的酶，参与基因编码的蛋白质合成，催化蛋白质中赖氨酸残基丙酰化，从而调节蛋白质功能。本文综述了AARS1/2参与蛋白质误翻译诱导的疾病进展和代谢-免疫相互作用网络调控的研究进展，旨在更好地了解AARS1/2的病理生理机制，为潜在治疗药物的开发提供参考。

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AARS1/2: dual functions in protein translation and metabolic- immune regulation.

Highly precise regulation of protein synthesis is critical for the homeostasis and functionality of living organisms. Alanyl-tRNA synthase (AARS1/2) plays a crucial role in this process. AARS1/2 are a class of enzymes that synthesize alanyl-tRNA in cells, participating in protein synthesis encoded by genes, and catalyzing the propionylation of lysine residues in proteins, thereby regulating protein function. This article reviews the research progress on the involvement of AARS1/2 in disease progression induced by protein mistranslation and in the regulation of the metabolic-immune interaction network, aiming to better understand the pathophysiological mechanisms of AARS1/2 and to provide a reference for the development of potential therapeutic drugs.

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.