原发性Sjögren综合征患者低频波动的频率依赖性和时间变异性

IF 3.5 2区 医学 Q1 RHEUMATOLOGY
Chunfeng Hu, Luoyu Wang, Xiuhong Ge, Zhijiang Han, Xiaofang Zhang, Xinyun Du, Yushan Shang, Huijun Cao, Chengcheng Gao, Peiying Wei, Jiao Huang
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引用次数: 0

摘要

目的:中枢神经系统是原发性Sjögren综合征(pSS)的一个重要的腺外靶点,通常以认知缺陷为特征。然而,潜在的机制仍然难以捉摸。本研究旨在探讨pSS患者低频波动幅度(ALFF)的变化,并探讨其是否具有频率依赖性和时间变异性,试图探讨其机制。方法:研究纳入68例pSS患者和69名健康对照者,所有患者均接受静息状态功能MRI和神经心理学评估。ALFF方法用于确定频率相关的变化是否发生在慢5 (0.01-0.027 Hz)和慢4 (0.027-0.073 Hz)频段内。此外,还进行了动态ALFF (dALFF)分析,以探讨时间变异。最后,阐明了异常脑区与神经心理学评估之间的相关性。结果:pSS患者右侧梭状回ALFF及其两个亚带出现异常,左侧中央前回和右侧额中回仅在慢-5频段出现异常增高。pSS患者左辅助运动区dALFF表现出异常活动。此外,ALFF慢5频段识别的脑区差异与某些神经心理学量表相关。结论:本研究表明,ALFF指标可以更好地了解pSS患者区域脑功能的变化,这些变化具有频率依赖性和时间变异性特征,补充了传统的指标,增强了我们对pSS脑功能的理解,并表明ALFF可能成为探索pSS患者潜在神经机制的新工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren's syndrome.

Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren's syndrome.

Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren's syndrome.

Objectives: The central nervous system is a significant extraglandular target in primary Sjögren's syndrome (pSS), often characterised by cognitive deficits. However, the underlying mechanisms remain elusive. This study aims to investigate the alterations in amplitude of low-frequency fluctuations (ALFF) in patients with pSS and to explore whether it exhibits frequency dependence and temporal variability, attempting to explore its mechanism.

Methods: The study comprised 68 patients with pSS and 69 healthy controls, all of whom underwent resting-state functional MRI and neuropsychological assessments. The ALFF method was used to ascertain whether frequency-dependent alterations occur within the slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) frequency bands. Additionally, dynamic ALFF (dALFF) analysis was conducted to explore the temporal variability. Ultimately, the correlation between the abnormal brain regions and neuropsychological assessments was elucidated.

Results: The right fusiform gyrus of patients with pSS shows abnormalities in ALFF and its two sub-bands, while the left precentral gyrus and right middle frontal gyrus exhibited abnormal increase limited to the slow-5 frequency band. dALFF showed an abnormal activity in the left supplementary motor area in patients with pSS. Additionally, the differential brain regions identified by the slow-5 frequency band of ALFF correlated with certain neuropsychological scales.

Conclusions: This research indicates that ALFF metrics offer enhanced insights into the alterations of regional brain function in patients with pSS, which exhibits both frequency-dependent and temporal variability characteristics, complementing traditional metrics and enhancing our comprehension of brain function in pSS and suggests that ALFF may emerge as a novel instrument for exploring the underlying neural mechanisms in patients with pSS.

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来源期刊
Lupus Science & Medicine
Lupus Science & Medicine RHEUMATOLOGY-
CiteScore
5.30
自引率
7.70%
发文量
88
审稿时长
15 weeks
期刊介绍: Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.
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