{"title":"年轻晚期乳腺癌患者超声特征与肿瘤细胞增殖、侵袭及凋亡分子标志物的关系","authors":"Hongmei Zhang, Lili Hu, Ping Li, Ge Sun","doi":"10.1111/jog.70073","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aimed to investigate the correlation between ultrasonographic features and the expression of genes (as molecular markers) related to cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 203 young patients with advanced breast cancer admitted to our hospital were enrolled and divided into a deceased group (<i>n</i> = 52) and a survival group (<i>n</i> = 151) based on overall survival status. Ultrasonographic features and expression levels of proliferation- (PKM2, Notch1), invasion-(Gab2, NUAK1), and apoptosis-related (Bcl-2) genes were compared between groups. The correlation between the Ki67 proliferation index and ultrasonographic features was also analyzed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Significant differences between the deceased and survival groups were identified in internal echogenicity, margin, morphology, blood flow grade, BI-RADS classification, and calcification (<i>p</i> <0.05). The deceased group exhibited significantly higher expression levels of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (<i>p</i> <0.05). Spearman analysis revealed significant positive correlations between adverse ultrasonographic features and the expression of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (<i>p</i> <0.01). Furthermore, Ki67 expression levels were significantly positively correlated with adverse features such as irregular margins, irregular morphology, and higher blood flow grade (<i>p</i> <0.01).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Proliferation-related genes (PKM2, Notch1), invasion-related genes (Gab2, NUAK1), the apoptosis-related gene Bcl-2, and the proliferation marker Ki67 are positively correlated with specific ultrasonographic features in young patients with advanced breast cancer, suggesting a link between imaging phenotypes and molecular markers of aggressiveness.</p>\n </section>\n </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation between ultrasonographic features and molecular markers of cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer\",\"authors\":\"Hongmei Zhang, Lili Hu, Ping Li, Ge Sun\",\"doi\":\"10.1111/jog.70073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study aimed to investigate the correlation between ultrasonographic features and the expression of genes (as molecular markers) related to cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A total of 203 young patients with advanced breast cancer admitted to our hospital were enrolled and divided into a deceased group (<i>n</i> = 52) and a survival group (<i>n</i> = 151) based on overall survival status. Ultrasonographic features and expression levels of proliferation- (PKM2, Notch1), invasion-(Gab2, NUAK1), and apoptosis-related (Bcl-2) genes were compared between groups. The correlation between the Ki67 proliferation index and ultrasonographic features was also analyzed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Significant differences between the deceased and survival groups were identified in internal echogenicity, margin, morphology, blood flow grade, BI-RADS classification, and calcification (<i>p</i> <0.05). The deceased group exhibited significantly higher expression levels of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (<i>p</i> <0.05). Spearman analysis revealed significant positive correlations between adverse ultrasonographic features and the expression of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (<i>p</i> <0.01). Furthermore, Ki67 expression levels were significantly positively correlated with adverse features such as irregular margins, irregular morphology, and higher blood flow grade (<i>p</i> <0.01).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Proliferation-related genes (PKM2, Notch1), invasion-related genes (Gab2, NUAK1), the apoptosis-related gene Bcl-2, and the proliferation marker Ki67 are positively correlated with specific ultrasonographic features in young patients with advanced breast cancer, suggesting a link between imaging phenotypes and molecular markers of aggressiveness.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16593,\"journal\":{\"name\":\"Journal of Obstetrics and Gynaecology Research\",\"volume\":\"51 9\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetrics and Gynaecology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70073\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynaecology Research","FirstCategoryId":"3","ListUrlMain":"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70073","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Correlation between ultrasonographic features and molecular markers of cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer
Objective
This study aimed to investigate the correlation between ultrasonographic features and the expression of genes (as molecular markers) related to cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer.
Methods
A total of 203 young patients with advanced breast cancer admitted to our hospital were enrolled and divided into a deceased group (n = 52) and a survival group (n = 151) based on overall survival status. Ultrasonographic features and expression levels of proliferation- (PKM2, Notch1), invasion-(Gab2, NUAK1), and apoptosis-related (Bcl-2) genes were compared between groups. The correlation between the Ki67 proliferation index and ultrasonographic features was also analyzed.
Results
Significant differences between the deceased and survival groups were identified in internal echogenicity, margin, morphology, blood flow grade, BI-RADS classification, and calcification (p <0.05). The deceased group exhibited significantly higher expression levels of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (p <0.05). Spearman analysis revealed significant positive correlations between adverse ultrasonographic features and the expression of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (p <0.01). Furthermore, Ki67 expression levels were significantly positively correlated with adverse features such as irregular margins, irregular morphology, and higher blood flow grade (p <0.01).
Conclusion
Proliferation-related genes (PKM2, Notch1), invasion-related genes (Gab2, NUAK1), the apoptosis-related gene Bcl-2, and the proliferation marker Ki67 are positively correlated with specific ultrasonographic features in young patients with advanced breast cancer, suggesting a link between imaging phenotypes and molecular markers of aggressiveness.
期刊介绍：
The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology.
The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
