多酚结合g4 -四重结构,作为具有抗癌作用的表观遗传修饰剂。

IF 4.9 3区 生物学 Q1 BIOLOGY
EXCLI Journal Pub Date : 2025-08-01 eCollection Date: 2025-01-01 DOI:10.17179/excli2025-8507
Marco Antonio Meraz-Rodriguez, Manuel Humberto Cháirez-Ramírez, Karen Griselda de la Cruz-López, Rubén Francisco González-Laredo, Alejandro García-Carrancá
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引用次数: 0

摘要

g4 -四plex (G4s)是核酸的非规范结构,在DNA和RNA的富含鸟嘌呤的区域发育。由于它们存在于致癌启动子和端粒中,G4s在抗癌药物设计中是有吸引力的靶点。G4s也是最近研究的主题,因为它们作为表观遗传调节剂的作用,支持它们参与控制基因表达的表观遗传过程。优先靶向G4s的小化合物的开发使人们更好地了解G4s如何控制这些机制。天然产物极大地促进了许多具有优异抗癌活性的化合物的成功开发。因此,研究膳食多酚及其衍生物等天然产物中靶向g4 -四聚物的配体具有重要意义。本文综述了近年来天然化合物的研究进展,重点介绍了膳食多酚作为g4 -四联靶配体的研究进展。我们还讨论了膳食多酚的结构化学,可以促进它们作为G4配体的表征,强调它们在抗癌药物开发中的潜力。最后,我们探讨了多酚通过G4结合调控表观遗传机制的潜在作用机制,从而为开发安全有效的抗癌治疗工具提供见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects.

Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects.

Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects.

Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects.

G4-quadruplexes (G4s) are non-canonical structures of nucleic acids that develop in guanine rich regions of DNA and RNA. Due to their presence in oncogenic promoters and telomeres, G4s represent attractive targets in anticancer drug designs. G4s have also been the subject of recent research regarding their role as epigenetic modulators, supporting their participation in epigenetic processes that control gene expression. The development of small compounds that preferentially target G4s have led to a better understanding of how G4s control these mechanisms. Natural products have greatly contributed to the development of many successful examples of compounds with excellent anticancer activities. Therefore, it is important to investigate ligands targeting G4-quadruplexes in natural products such as dietary polyphenols and their derivatives. In this review, we provide an overview of the latest research on natural compounds, with especial emphasis on dietary polyphenols, as G4-quadruplex targeted ligands. We also discuss dietary polyphenols' structural chemistry that could facilitate their characterization as G4 ligands, highlighting their potential in the development of anticancer drugs. Finally, we explore polyphenols' potential mechanisms of action in regulating epigenetic machinery through G4 binding, thereby providing insights for the development of safe and effective therapeutical tools against cancer.

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来源期刊
EXCLI Journal
EXCLI Journal BIOLOGY-
CiteScore
8.00
自引率
2.20%
发文量
65
审稿时长
6-12 weeks
期刊介绍: EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences. The journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged (alphabetical order): aging research, behavioral sciences, biochemistry, cell biology, chemistry including analytical chemistry, clinical and preclinical studies, drug development, environmental health, ergonomics, forensic medicine, genetics, hepatology and gastroenterology, immunology, neurosciences, occupational medicine, oncology and cancer research, pharmacology, proteomics, psychiatric research, psychology, systems biology, toxicology
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