肿瘤发生中的MAPK/ERK信号:生长、侵袭和血管生成的机制。

IF 4.9 3区 生物学 Q1 BIOLOGY
EXCLI Journal Pub Date : 2025-07-23 eCollection Date: 2025-01-01 DOI:10.17179/excli2025-8479
Jiaying Fei, Yanjun Guo
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引用次数: 0

摘要

ERK1/2在肿瘤发生过程中的重要性已经引起了相当大的兴趣,因为它在各种细胞机制中发挥重要作用,特别是与癌症的发生和进展有关。Ras-Raf-MAPK信号级联负责激活ERK1/2,在肿瘤细胞生长、侵袭和新血管形成的调控中起着至关重要的作用。最近的研究强调了ERK1/2激活机制的复杂性质及其对肿瘤生物学的后续影响,说明了与该途径调节相关的致癌能力和治疗障碍。尽管对ERK1/2信号的理解取得了进展,但仍存在许多挑战,包括针对该途径的治疗出现耐药性,以及需要更多选择性抑制剂。本综述旨在整合有关ERK1/2及其在Ras-Raf-MAPK通路中的调控作用的最新科学发现,为这些相互作用如何促进肿瘤增殖和转移提供见解。通过阐明ERK1/2信号与肿瘤生物学之间的联系,本文希望有助于在癌症治疗的背景下制定旨在中断该途径的新治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

MAPK/ERK Signaling in Tumorigenesis: mechanisms of growth, invasion, and angiogenesis.

MAPK/ERK Signaling in Tumorigenesis: mechanisms of growth, invasion, and angiogenesis.

MAPK/ERK Signaling in Tumorigenesis: mechanisms of growth, invasion, and angiogenesis.

MAPK/ERK Signaling in Tumorigenesis: mechanisms of growth, invasion, and angiogenesis.

The significance of ERK1/2 in the process of tumorigenesis has attracted considerable interest owing to its essential role in a variety of cellular mechanisms, especially in relation to cancer initiation and progression. The Ras-Raf-MAPK signaling cascade, responsible for the activation of ERK1/2, plays a vital role in the regulation of tumor cell growth, invasion, and the formation of new blood vessels. Recent research has underscored the intricate nature of the mechanisms by which ERK1/2 is activated and the subsequent implications for tumor biology, illustrating both the oncogenic capabilities and the therapeutic hurdles linked to the modulation of this pathway. Despite progress in the comprehension of ERK1/2 signaling, numerous challenges persist, including the emergence of resistance to therapies that target this pathway, alongside the necessity for more selective inhibitors. This review intends to consolidate the most recent scientific discoveries pertaining to ERK1/2 and its regulatory influence within the Ras-Raf-MAPK pathway, offering insights into how these interactions facilitate tumor proliferation and metastasis. By clarifying the connection between ERK1/2 signaling and tumor biology, this article aspires to contribute to the formulation of novel therapeutic approaches aimed at interrupting this pathway in the context of cancer treatment.

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来源期刊
EXCLI Journal
EXCLI Journal BIOLOGY-
CiteScore
8.00
自引率
2.20%
发文量
65
审稿时长
6-12 weeks
期刊介绍: EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences. The journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged (alphabetical order): aging research, behavioral sciences, biochemistry, cell biology, chemistry including analytical chemistry, clinical and preclinical studies, drug development, environmental health, ergonomics, forensic medicine, genetics, hepatology and gastroenterology, immunology, neurosciences, occupational medicine, oncology and cancer research, pharmacology, proteomics, psychiatric research, psychology, systems biology, toxicology
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