Pratik M Kadam, Vitthal T Barvkar, Swaranjali S Patil, Shubham B Ahirrao, Smita S Zinjarde
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In the presence of 0.1 mM isopropyl β-D-1-thiogalactopyranoside (IPTG) as an inducer, 31.52 mg/g cell dry weight (CDW) of ectoine was obtained. After inclusion of 200 mM L-aspartic acid as precursor, this content was further enhanced to 131.41 mg/g CDW. With the acquired ability to produce ectoine, the recombinant strain tolerated sodium chloride (NaCl) up to a level of 5%. Compared to the original organism that produced 40.78 mg/g CDW of ectoine after 48 h in medium containing 5% NaCl, the recombinant produced higher content of ectoine (131.41 mg/g CDW) after 24 h of incubation in the absence of salt. On account of these features, the process of ectoine production by the recombinant was deemed effectual and economically lucrative for large-scale production. 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引用次数: 0
摘要
异托碱是一种由多种细菌产生的天然细胞保护剂,具有商业价值。在这项研究中,利用一种新的方法对大肠杆菌BL21(DE3)进行了改造,使其产生异托因。对达森诺卡opsis dassonvillei NCIM 5124的ectABC基因簇进行了密码子优化,设计了基于pET-24a(+)的构建体(pEctoineCAB)。引入两个元件- p2a标签(来自导致核糖体跳跃的猪teschovirus-1)和IRES序列(来自脑心肌炎病毒的内部核糖体进入位点),以确保与外泌素产生相关的所有酶的充分表达水平。对含有pEctoineCAB的转化物的异质生物合成能力进行了评价。以0.1 mM的异丙基β- d -1-硫代半乳糖苷(IPTG)为诱导剂,外托因的细胞干重为31.52 mg/g。在加入200 mM l -天冬氨酸作为前体后,该含量进一步提高到131.41 mg/g CDW。由于获得了生产外托因的能力,重组菌株耐受氯化钠(NaCl)高达5%的水平。在含5% NaCl的培养基中培养48 h后,重组菌的体外托碱含量为40.78 mg/g CDW,而在无盐条件下培养24 h后,重组菌的体外托碱含量为131.41 mg/g CDW。由于这些特点,重组生产异托碱的工艺被认为是有效的,经济上有利可图的大规模生产。这是首次报道在大肠杆菌中使用P2A标签来有效生产具有重要经济意义的产品。
Coexpression of the Ectoine Biosynthetic Gene Cluster from Nocardiopsis dassonvillei NCIM 5124 in Escherichia coli by Using a Novel Strategy.
Ectoine, a natural cell protectant produced by a variety of bacteria has commercial value. In this study, Escherichia coli BL21(DE3) was engineered for producing ectoine by using a novel approach. The ectABC gene cluster from Nocardiopsis dassonvillei NCIM 5124 was codon optimized for E. coli and a pET-24a(+) based construct (pEctoineCAB) was designed. Two elements-P2A tag (derived from porcine teschovirus-1 that causes ribosomal skipping) and IRES sequence (internal ribosome entry site from encephalomyocarditis virus) were introduced to ensure sufficient expression levels of all the enzymes relevant to ectoine production. The ability of the transformant harbouring pEctoineCAB was evaluated for its ectoine biosynthetic capability. In the presence of 0.1 mM isopropyl β-D-1-thiogalactopyranoside (IPTG) as an inducer, 31.52 mg/g cell dry weight (CDW) of ectoine was obtained. After inclusion of 200 mM L-aspartic acid as precursor, this content was further enhanced to 131.41 mg/g CDW. With the acquired ability to produce ectoine, the recombinant strain tolerated sodium chloride (NaCl) up to a level of 5%. Compared to the original organism that produced 40.78 mg/g CDW of ectoine after 48 h in medium containing 5% NaCl, the recombinant produced higher content of ectoine (131.41 mg/g CDW) after 24 h of incubation in the absence of salt. On account of these features, the process of ectoine production by the recombinant was deemed effectual and economically lucrative for large-scale production. This is the first report on the use of P2A tag in E. coli for effective production of an economically important product.
期刊介绍:
Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment.
Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas:
physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.