靶向IL-4/IL-13信号通路在慢性鼻窦炎伴鼻息肉中的作用：从机制到治疗

IF 11.3 2区医学 Q1 ALLERGY

Clinical Reviews in Allergy & Immunology Pub Date : 2025-09-18 DOI:10.1007/s12016-025-09097-4

Jiani Chen, Chen Zhang, Qianqian Zhang, Fuying Cheng, Yizhang Wang, Shirui Xue, Yufei Yang, Wenwen Guo, Juan Liu, Kai Xue, Yaguang Zhang, Dehui Wang, Li Hu, Huan Wang, Xicai Sun

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引用次数: 0

摘要

慢性鼻窦炎伴鼻息肉（CRSwNP）是一种常见的上呼吸道炎症性疾病，其特征是鼻窦黏膜持续炎症并形成鼻息肉。白细胞介素(IL)-4/IL-13信号通路在CRSwNP发病机制中的关键作用越来越被认识到，靶向该通路的生物制剂的显著临床成功证明了这一点。本文综述了CRSwNP中IL-4/IL-13通路，包括其分子结构、致病机制、目前的靶向治疗和新出现的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.

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来源期刊

Clinical Reviews in Allergy & Immunology 医学-过敏

CiteScore

22.30

自引率

1.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.