利用斑马鱼作为光药理学的模型：对光转换药物的光控生物效应的见解。

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-10-01 DOI:10.1016/j.drudis.2025.104477

Guilherme Pietro da Silva , Janine Doorduin , Wiktor Szymanski , Rosane Souza da Silva , Philip Elsinga , Carla Denise Bonan

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引用次数: 0

摘要

光药理学是一个新兴的药理学领域，它能够对药物的光激活进行精确的时空控制。在可逆模式下，它依赖于光切换的生物活性化合物。可逆激活和灭活由光开关衍生的药物的能力使我们能够避免副作用和环境毒性。斑马鱼由于其在早期发育阶段的光学透明性、遗传易感性和良好的生物学机制特征，代表了一种新兴的、优越的翻译光药理学模型。在这篇综述中，我们讨论了斑马鱼在推进光药理学和理解利用光切换生物活性化合物进行光控干预的作用方面的应用。

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Harnessing zebrafish as a model for photopharmacology: Insights into light-controlled biological effects of photoswitchable drugs

Photopharmacology is an emerging field of pharmacological sciences that enables precise spatiotemporal control over drug activation with light. In its reversible mode, it relies on photoswitchable bioactive compounds. The capacity to reversibly activate and deactivate drugs derivatized with photoswitches enables us to avoid side effects and environmental toxicity. Zebrafish represent an emerging and privileged model for translational photopharmacology because of their optical transparency at early developmental stages, genetic tractability, and well-characterized biological mechanisms. In this review, we discuss the use of zebrafish in advancing photopharmacology and understanding the effects of light-controlled interventions using photoswitchable bioactive compounds.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.