Christopher T. W. Tsang, Sylvia E. Choi, Tommaso Bucci, Alfred C. W. Lau, Qing-Wen Ren, Jia-Yi Huang, Mei-Zhen Wu, Wen-Li Gu, Ran Guo, Jing-Nan Zhang, Yuen-Ching Ng, Benjamin J. R. Buckley, Jan F. Scheitz, Yap-Hang Chan, Kui-Kai Lau, Hung-Fat Tse, Azmil H. Abdul-Rahim, Gregory Y. H. Lip, Kai-Hang Yiu
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Multivariable Fine–Gray competing risk analysis was performed after 1:1 propensity score matching to evaluate the association between SHS and the risk of dementia.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS. Patients with SHS had a 19% increased risk of dementia compared to those without SHS at 1 year post-stroke, driven mainly by vascular dementia. This increased risk gradually declined and became non-significant after 3 years post-stroke. Appropriate antithrombotic therapy and comorbidities optimization were associated with a 32% reduced dementia risk in patients with SHS.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>SHS is associated with an increased risk of incident dementia. 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Stroke–heart syndrome and risk of incident dementia among patients with first-ever ischemic stroke: A territory-wide population-based cohort study
INTRODUCTION
The risk of dementia in patients with ischemic stroke and early cardiovascular complications (i.e., stroke–heart syndrome [SHS]) remains underexplored.
METHODS
Patients with first-ever ischemic stroke in Hong Kong between 2005 and 2020 were included. Multivariable Fine–Gray competing risk analysis was performed after 1:1 propensity score matching to evaluate the association between SHS and the risk of dementia.
RESULTS
Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS. Patients with SHS had a 19% increased risk of dementia compared to those without SHS at 1 year post-stroke, driven mainly by vascular dementia. This increased risk gradually declined and became non-significant after 3 years post-stroke. Appropriate antithrombotic therapy and comorbidities optimization were associated with a 32% reduced dementia risk in patients with SHS.
DISCUSSION
SHS is associated with an increased risk of incident dementia. Appropriate antithrombotic therapy and comorbidities optimization post-stroke may reduce this heightened risk of cognitive impairment.
Highlights
Association between stroke–heart syndrome (SHS) and dementia was evaluated in a population-based cohort.
Development of SHS associated with a 19% increased 1 year risk of dementia.
The increased risk of dementia gradually declined with each year of follow-up.
Integrated post-stroke management may reduce this heightened risk of cognitive impairment.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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