Jiayi Chao, Rumeng Yang, Jiarui Huang, Xi Chen, Xian-Rong Song and Qiang Xiao
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Advances in the direct transformations of propargylic alcohols and sulphur-containing reagents
Sulphur-containing compounds are regarded as an important class of organic compounds that are widely applied in pharmaceuticals, agriculture, materials sciences, natural products, and organic synthesis. Consequently, the development of synthetic strategies for sulphur-containing compounds has become a prominent research topic in synthetic chemistry. Additionally, propargylic alcohols with unique bifunctional groups have emerged as promising and versatile synthons in organic synthesis. Over the past few decades (until the present), considerable efforts have been made to construct these compounds through the direct transformation of propargylic alcohols with various sulphur-containing reagents. This review systematically highlights these advances in the direct transformation of propargylic alcohols with sulphur-containing reagents for the construction of sulphur-containing compounds. Based on the different reaction mechanisms underlying these transformations, this review is divided into four sections: (1) base-promoted direct transformation of propargylic alcohols with sulphur-containing reagents; (2) acid-promoted/catalyzed direct transformation of propargylic alcohols with sulphur-containing reagents; (3) metal-catalyzed direct transformation of propargylic alcohols with sulphur-containing reagents; and (4) radical transformation of propargylic alcohols with sulphur-containing reagents.
期刊介绍:
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.