探索香草酸胶束系统在骨关节炎治疗中的关节内输送。

IF 3.6 3区 医学 Q2 CHEMISTRY, MEDICINAL
Shaimaa S. Ibrahim, Hend Abd-allah
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引用次数: 0

摘要

本研究旨在探讨一种治疗膝骨关节炎(KOA)的新方法。为此,我们开发了混合聚合物胶束(MPM)包封天然植物治疗药物香草酸(VA),用于关节内(IA)递送。通过粒径分布、zeta电位、形貌、物理稳定性和体外释药等指标对所制备体系进行了表征。研究发现,Cremophor是生产具有最佳粒径分布的MPM的重要组成部分,并保持F127/Cremophor/TPGS的重量比为3:2:1。在单碘乙酸钠诱导的大鼠KOA模型中,用透明质酸(HA)包覆优化的配方具有维持VA释放和协同抗骨关节炎活性的双重益处。所提出的ha包被的MPM系统封装VA为抑制KOA的进展提供了一种有前途的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring Micellar Systems for Intra-Articular Delivery of Vanillic Acid in Management of Osteoarthritis

The current research investigates a new therapeutic strategy for the management of knee osteoarthritis (KOA). For this purpose, we developed mixed polymeric micelles (MPM) encapsulating a natural phytotherapeutic drug, vanillic acid (VA), for intra-articular (IA) delivery. The developed systems were characterized by their particle size profile, zeta potential, morphology, physical stability, and in vitro drug release. Cremophor was found to be an essential component for the production of MPM with optimum particle size profile, as well as maintaining an F127/Cremophor/TPGS weight ratio of 3:2:1. Coating the optimized formulation with hyaluronic acid (HA) provided a dual benefit of sustaining VA release and providing synergistic anti-osteoarthritic activity in an monosodiumiodoacetate-induced KOA model in rats. The proposed HA-coated MPM system encapsulating VA provides a promising strategy for the inhibition of KOA progression.

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来源期刊
Archiv der Pharmazie
Archiv der Pharmazie 医学-化学综合
CiteScore
7.90
自引率
5.90%
发文量
176
审稿时长
3.0 months
期刊介绍: Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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