Phuong Thuy Nguyen Ho, Meike W. Vernooij, Trudy Voortman, María Rodriguez-Ayllon, Julia Neitzel
{"title":"目的：以人群为基础的鹿特丹研究中体力活动与阿尔茨海默病负担的关系。","authors":"Phuong Thuy Nguyen Ho, Meike W. Vernooij, Trudy Voortman, María Rodriguez-Ayllon, Julia Neitzel","doi":"10.1002/alz.70655","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Physical activity is linked to lower dementia risk, but its connection to Alzheimer's disease (AD) pathology remains uncertain. This study examined the relationship between objectively measured physical activity and early AD biomarkers in cognitively unimpaired adults.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Accelerometer-measured physical activity and plasma AD biomarkers (beta-amyloid [Aβ]42/Aβ40, p-tau217) were assessed in 242 participants (age = 63.37 [54–79] years) of the population-based Rotterdam Study. Cortical Aβ was assessed via <sup>18</sup>F-florbetaben positron emission tomography (PET) 7 years later. Robust regression assessed the relationship between physical activity, plasma AD biomarkers, and Aβ PET burden, while compositional analysis examined how the time-use composition relates to AD outcomes.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Physical activity was not associated with plasma Aβ42/Aβ40, p-tau217, or brain Aβ burden 7 years later. Reallocating awake sedentary time to physical activity showed no association with AD biomarkers.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>No relationship was identified between physical activity and AD biomarkers, suggesting physical activity might affect dementia risk through other pathways or in an earlier life phase.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Physical activity was not associated with plasma beta-amyloid (Aβ)42/Aβ40 nor p-tau217.</li>\n \n <li>No association was observed between physical activity and brain Aβ 7 years later.</li>\n \n <li>Age, sex, and apolipoprotein E ε4 carriership did not moderate these relationships.</li>\n \n <li>Reallocating 30 minutes of sedentary time to physical activity resulted in no change in Alzheimer's disease (AD) biomarkers.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445197/pdf/","citationCount":"0","resultStr":"{\"title\":\"Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study\",\"authors\":\"Phuong Thuy Nguyen Ho, Meike W. 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Robust regression assessed the relationship between physical activity, plasma AD biomarkers, and Aβ PET burden, while compositional analysis examined how the time-use composition relates to AD outcomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Physical activity was not associated with plasma Aβ42/Aβ40, p-tau217, or brain Aβ burden 7 years later. Reallocating awake sedentary time to physical activity showed no association with AD biomarkers.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>No relationship was identified between physical activity and AD biomarkers, suggesting physical activity might affect dementia risk through other pathways or in an earlier life phase.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Physical activity was not associated with plasma beta-amyloid (Aβ)42/Aβ40 nor p-tau217.</li>\\n \\n <li>No association was observed between physical activity and brain Aβ 7 years later.</li>\\n \\n <li>Age, sex, and apolipoprotein E ε4 carriership did not moderate these relationships.</li>\\n \\n <li>Reallocating 30 minutes of sedentary time to physical activity resulted in no change in Alzheimer's disease (AD) biomarkers.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 9\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445197/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70655\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70655","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study
INTRODUCTION
Physical activity is linked to lower dementia risk, but its connection to Alzheimer's disease (AD) pathology remains uncertain. This study examined the relationship between objectively measured physical activity and early AD biomarkers in cognitively unimpaired adults.
METHODS
Accelerometer-measured physical activity and plasma AD biomarkers (beta-amyloid [Aβ]42/Aβ40, p-tau217) were assessed in 242 participants (age = 63.37 [54–79] years) of the population-based Rotterdam Study. Cortical Aβ was assessed via 18F-florbetaben positron emission tomography (PET) 7 years later. Robust regression assessed the relationship between physical activity, plasma AD biomarkers, and Aβ PET burden, while compositional analysis examined how the time-use composition relates to AD outcomes.
RESULTS
Physical activity was not associated with plasma Aβ42/Aβ40, p-tau217, or brain Aβ burden 7 years later. Reallocating awake sedentary time to physical activity showed no association with AD biomarkers.
DISCUSSION
No relationship was identified between physical activity and AD biomarkers, suggesting physical activity might affect dementia risk through other pathways or in an earlier life phase.
Highlights
Physical activity was not associated with plasma beta-amyloid (Aβ)42/Aβ40 nor p-tau217.
No association was observed between physical activity and brain Aβ 7 years later.
Age, sex, and apolipoprotein E ε4 carriership did not moderate these relationships.
Reallocating 30 minutes of sedentary time to physical activity resulted in no change in Alzheimer's disease (AD) biomarkers.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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