用钯纳米催化剂合成2-苯基吲哚的无配体碳氢功能化及其抗癌潜力。

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2025-09-04 DOI:10.1039/D5TB01178G

Harini G. Sampatkumar, S. Likitha, Maruboina Hemanth Kumar, M. S. Sudhanva, C. V. Yelamaggad, Ramesh B. Dateer, Kiran B. Manjappa and Siddappa A. Patil

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引用次数: 0

摘要

我们报道了一种可持续的，磁性可分离的Pd@FO-BCN纳米催化剂，具有最小的Pd负载，用于2-苯基吲哚合成中有效的无配体C-H功能化。这种新型异质体系具有广泛的官能团耐受性、高可回收性和优异的收率。值得注意的是，5-乙酰-2-苯基吲哚显示出有希望的抗癌活性，突出了纳米催化剂在生物医学上的相关性以及在制药和材料化学方面的应用潜力。

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Ligand-free C–H functionalization using a palladium nanocatalyst for the synthesis of 2-phenylindoles and their anticancer potential

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Ligand-free C–H functionalization using a palladium nanocatalyst for the synthesis of 2-phenylindoles and their anticancer potential

We report a sustainable, magnetically separable Pd@FO-BCN nanocatalyst with minimal Pd loading for efficient ligand-free C–H functionalization in 2-phenylindole synthesis. This novel heterogeneous system shows broad functional group tolerance, high recyclability and excellent yields. Notably, 5-acetyl-2-phenylindole displayed promising anticancer activity, highlighting the nanocatalyst's biomedical relevance and potential for pharmaceutical and materials chemistry applications.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices