解码慢性子宫内膜炎的多因素病因。

IF 2.5 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2025-09-10 DOI:10.1016/j.placenta.2025.09.007

Guanying You, Shuyi Yu, Meng Liu, Lianghui Diao, Ruochun Lian, Yuye Li

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引用次数: 0

摘要

慢性子宫内膜炎（CE）是一种持续的子宫内膜炎症性疾病，典型特征是异常浆细胞浸润。它与不良妊娠结局密切相关。CE的发病机制涉及感染性和非感染性因素的复杂相互作用。感染病因包括上行感染途径、盆腔感染途径、性传播、血液感染途径和特殊感染，非感染因素包括子宫结构病理、自身免疫性疾病和医源性因素。考虑到CE的多因素病因，采用结合微生物和免疫因素的个性化管理方法可能会提高CE妇女的妊娠结局。

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Decoding the multifactorial etiology of chronic endometritis.

Chronic endometritis (CE) is a persistent inflammatory disorder of the endometrium, typically marked by abnormal plasma cell infiltration. It is closely associated with adverse pregnancy outcomes. The pathogenesis of CE involves a complex interplay of both infectious and non-infectious factors. Infectious etiologies include ascending infection pathways, pelvic infection pathways, sexually transmission, hematogenous infection pathways and special infections, while non-infectious factors encompass uterine structural pathology, autoimmune disorders and iatrogenic factors. Considering the multifactorial etiology of CE, adopting a personalized management approach that integrates both microbial and immune factors may enhance pregnancy outcomes for CE women.

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.