A K Erickson, G Tremolada, K E Sztukowski, D H Thamm, B D Husbands
{"title":"犬手指和远端肢体皮肤和皮下肥大细胞肿瘤手术切除的临床、病理和预后特点。","authors":"A K Erickson, G Tremolada, K E Sztukowski, D H Thamm, B D Husbands","doi":"10.1111/jsap.70020","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate clinical, pathological and prognostic features and outcomes of dogs with surgically excised cutaneous and subcutaneous digital or distal limb mast cell tumours.</p><p><strong>Materials and methods: </strong>Medical records between 2014 and 2024 were reviewed, and signalment, clinicopathological testing, tumour location, recurrence, complications and histological characteristics were recorded. Additionally, progression-free interval and overall survival time were evaluated. One hundred and fifteen client-owned dogs with mast cell tumour admitted to two academic institutions were included.</p><p><strong>Results: </strong>Surgical complications occurred in 38% of dogs with surgical site infection and incisional dehiscence most common. Local recurrence occurred in 23% of dogs overall, with completely excised tumours having 10% recurrence, narrowly excised 20% and incompletely excised 35%. Higher recurrence rates occurred with incomplete surgical margins, mitotic count >5 and histologically high-grade mast cell tumours. The median progression-free interval was significantly longer for wide excision (2270 days) compared to marginal excision (888 days). The overall survival time was 7 years for all dogs overall, was not reached for low-grade mast cell tumours and was 3 years for high-grade mast cell tumours. The progression-free interval and overall survival time were affected by tumour grade but not lymph node status.</p><p><strong>Clinical significance: </strong>The behaviour of canine mast cell tumours affecting the digits and distal limb was affected primarily by tumours grade. Recurrence rates were highest in dogs with high-grade mast cell tumours, incomplete surgical resection and a mitotic count of >5. The outcome with surgical excision is excellent. Future studies are needed to further evaluate the effects of adjuvant chemotherapy, metastatic lymph node status and lymph node extirpation in high-grade mast cell tumour cases.</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical, pathological and prognostic features of surgically excised cutaneous and subcutaneous digital and distal limb mast cell tumours in dogs.\",\"authors\":\"A K Erickson, G Tremolada, K E Sztukowski, D H Thamm, B D Husbands\",\"doi\":\"10.1111/jsap.70020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate clinical, pathological and prognostic features and outcomes of dogs with surgically excised cutaneous and subcutaneous digital or distal limb mast cell tumours.</p><p><strong>Materials and methods: </strong>Medical records between 2014 and 2024 were reviewed, and signalment, clinicopathological testing, tumour location, recurrence, complications and histological characteristics were recorded. Additionally, progression-free interval and overall survival time were evaluated. One hundred and fifteen client-owned dogs with mast cell tumour admitted to two academic institutions were included.</p><p><strong>Results: </strong>Surgical complications occurred in 38% of dogs with surgical site infection and incisional dehiscence most common. Local recurrence occurred in 23% of dogs overall, with completely excised tumours having 10% recurrence, narrowly excised 20% and incompletely excised 35%. Higher recurrence rates occurred with incomplete surgical margins, mitotic count >5 and histologically high-grade mast cell tumours. The median progression-free interval was significantly longer for wide excision (2270 days) compared to marginal excision (888 days). The overall survival time was 7 years for all dogs overall, was not reached for low-grade mast cell tumours and was 3 years for high-grade mast cell tumours. The progression-free interval and overall survival time were affected by tumour grade but not lymph node status.</p><p><strong>Clinical significance: </strong>The behaviour of canine mast cell tumours affecting the digits and distal limb was affected primarily by tumours grade. Recurrence rates were highest in dogs with high-grade mast cell tumours, incomplete surgical resection and a mitotic count of >5. The outcome with surgical excision is excellent. Future studies are needed to further evaluate the effects of adjuvant chemotherapy, metastatic lymph node status and lymph node extirpation in high-grade mast cell tumour cases.</p>\",\"PeriodicalId\":17062,\"journal\":{\"name\":\"Journal of Small Animal Practice\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Small Animal Practice\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1111/jsap.70020\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Small Animal Practice","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jsap.70020","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Clinical, pathological and prognostic features of surgically excised cutaneous and subcutaneous digital and distal limb mast cell tumours in dogs.
Objective: To evaluate clinical, pathological and prognostic features and outcomes of dogs with surgically excised cutaneous and subcutaneous digital or distal limb mast cell tumours.
Materials and methods: Medical records between 2014 and 2024 were reviewed, and signalment, clinicopathological testing, tumour location, recurrence, complications and histological characteristics were recorded. Additionally, progression-free interval and overall survival time were evaluated. One hundred and fifteen client-owned dogs with mast cell tumour admitted to two academic institutions were included.
Results: Surgical complications occurred in 38% of dogs with surgical site infection and incisional dehiscence most common. Local recurrence occurred in 23% of dogs overall, with completely excised tumours having 10% recurrence, narrowly excised 20% and incompletely excised 35%. Higher recurrence rates occurred with incomplete surgical margins, mitotic count >5 and histologically high-grade mast cell tumours. The median progression-free interval was significantly longer for wide excision (2270 days) compared to marginal excision (888 days). The overall survival time was 7 years for all dogs overall, was not reached for low-grade mast cell tumours and was 3 years for high-grade mast cell tumours. The progression-free interval and overall survival time were affected by tumour grade but not lymph node status.
Clinical significance: The behaviour of canine mast cell tumours affecting the digits and distal limb was affected primarily by tumours grade. Recurrence rates were highest in dogs with high-grade mast cell tumours, incomplete surgical resection and a mitotic count of >5. The outcome with surgical excision is excellent. Future studies are needed to further evaluate the effects of adjuvant chemotherapy, metastatic lymph node status and lymph node extirpation in high-grade mast cell tumour cases.
期刊介绍：
Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery.
In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world.
The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher.
The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association
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