自限性戊型肝炎细胞因子和趋化因子的纵向分布。

IF 2.3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Pooja Bhatia, Aas Mohd, Harshita Katiyar, Amit Goel, Rakesh Aggarwal, Naga Suresh Veerapu
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引用次数: 0

摘要

戊型肝炎病毒感染通常导致自限性急性病毒性肝炎(AVH-E),可迅速被宿主免疫反应清除。在这项纵向研究中,使用多重免疫分析法分析了AVH-E患者血清中的时间细胞因子和趋化因子谱。HEV RNA在症状出现后的第9至18天(中位数为13天)无法检测到。在AVH-E组中,IFN-γ在HEV RNA清除期之前的第6-9天显著达到峰值,并在第9-18天下降。IL-2、IL-10和TNF-α在第15 ~ 20天显著升高,IL-1β和IL-6达到峰值。AVH-E组CCL3、CXCL6、CXCL9、CXCL10和MIF显著高于健康对照组;CCL2和CCL20在第12-17天达到峰值。AVH-E组CCL3、CXCL6、CXCL9、CXCL10水平低于AVH-B组。与AVH-B组和健康对照组相比,AVH-E组表现出明显的免疫特征。这些发现强调了HEV感染期间细胞因子和趋化因子的协调反应,并为自限性戊型肝炎的免疫发病机制提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal Profiles of Cytokines and Chemokines in Self-Limiting Hepatitis E

Hepatitis E virus infection typically results in a self-limited acute viral hepatitis (AVH-E), which is rapidly cleared by the host immune response. In this longitudinal study, temporal cytokine and chemokine profiles were analysed in AVH-E patients' sera using a multiplex immunoassay. HEV RNA became undetectable between 9 and 18 days, with a median of 13 days, occurring 3–20 days after symptom onset. In the AVH-E group, IFN-γ peaked significantly around days 6–9, which is prior to the HEV RNA clearance period, and declined during days 9–18. IL-2, IL-10, and TNF-α increased significantly during days 15–20, while IL-1β and IL-6 showed peak levels. CCL3, CXCL6, CXCL9, CXCL10 and MIF were significantly higher in the AVH-E group than in the healthy controls; CCL2 and CCL20 peaked non-significantly during days 12–17. CCL3, CXCL6, CXCL9 and CXCL10 levels were lower in the AVH-E group than in the AVH-B group. Compared to the AVH-B group and healthy controls, the AVH-E group showed distinct immune signatures. These findings highlight coordinated cytokine and chemokine responses during HEV infection and provide insights into the immunopathogenesis of self-limiting hepatitis E.

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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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