{"title":"氧化还原反应功能化介孔二氧化硅纳米颗粒靶向药物递送阿霉素。","authors":"Seyedeh Sahar Mojtabazadeh, Mahnoosh Samadi, Sahra Perseh, Saba Saei, Reza Bafkari, Fatemeh Atyabi, Rassoul Dinarvand","doi":"10.1080/1061186X.2025.2560592","DOIUrl":null,"url":null,"abstract":"<p><p>Mesoporous silica nanoparticles (MSNs) have been studied for the delivery of anticancer drugs because of their unique mesoporous channels. In this study, Biotin was used as a targeting moiety of MSNs for the purpose of breast cancer cell targeting, and then, Gelatine grafting onto the surface of MSNs was carried out using glutaraldehyde-mediated cross-linking as a capping layer. Dynamic light scattering (DLS), Zeta potential change, infra-red spectroscopy (FT-IR), nitrogen adsorption and desorption (BET), and transmission electron microscopy (TEM) was used for the characterisation of size, morphology and other features related to the fabricated nanoparticles (NPs). The gelatine/biotin coated MSNs (MSN@Bio-Gel) were loaded with Doxorubicin (DOX), followed by assessing its drug loading and release behaviour. <i>In vitro</i> experiments were carried out for exploring the antitumor effect of DOX-MSN@Bio-Gel. The size of NPs prepared in this study was in the range of 178-286 nm. The MTT assay showed suitable anticancer activity of the NPs.Confocal microscopy showed that gelatine-coated, biotin-targeted MSNs had higher cell uptake into MCF-7 cancer cells.</p>","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-11"},"PeriodicalIF":3.9000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin.\",\"authors\":\"Seyedeh Sahar Mojtabazadeh, Mahnoosh Samadi, Sahra Perseh, Saba Saei, Reza Bafkari, Fatemeh Atyabi, Rassoul Dinarvand\",\"doi\":\"10.1080/1061186X.2025.2560592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mesoporous silica nanoparticles (MSNs) have been studied for the delivery of anticancer drugs because of their unique mesoporous channels. In this study, Biotin was used as a targeting moiety of MSNs for the purpose of breast cancer cell targeting, and then, Gelatine grafting onto the surface of MSNs was carried out using glutaraldehyde-mediated cross-linking as a capping layer. Dynamic light scattering (DLS), Zeta potential change, infra-red spectroscopy (FT-IR), nitrogen adsorption and desorption (BET), and transmission electron microscopy (TEM) was used for the characterisation of size, morphology and other features related to the fabricated nanoparticles (NPs). The gelatine/biotin coated MSNs (MSN@Bio-Gel) were loaded with Doxorubicin (DOX), followed by assessing its drug loading and release behaviour. <i>In vitro</i> experiments were carried out for exploring the antitumor effect of DOX-MSN@Bio-Gel. The size of NPs prepared in this study was in the range of 178-286 nm. The MTT assay showed suitable anticancer activity of the NPs.Confocal microscopy showed that gelatine-coated, biotin-targeted MSNs had higher cell uptake into MCF-7 cancer cells.</p>\",\"PeriodicalId\":15573,\"journal\":{\"name\":\"Journal of Drug Targeting\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug Targeting\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/1061186X.2025.2560592\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Targeting","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1061186X.2025.2560592","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin.
Mesoporous silica nanoparticles (MSNs) have been studied for the delivery of anticancer drugs because of their unique mesoporous channels. In this study, Biotin was used as a targeting moiety of MSNs for the purpose of breast cancer cell targeting, and then, Gelatine grafting onto the surface of MSNs was carried out using glutaraldehyde-mediated cross-linking as a capping layer. Dynamic light scattering (DLS), Zeta potential change, infra-red spectroscopy (FT-IR), nitrogen adsorption and desorption (BET), and transmission electron microscopy (TEM) was used for the characterisation of size, morphology and other features related to the fabricated nanoparticles (NPs). The gelatine/biotin coated MSNs (MSN@Bio-Gel) were loaded with Doxorubicin (DOX), followed by assessing its drug loading and release behaviour. In vitro experiments were carried out for exploring the antitumor effect of DOX-MSN@Bio-Gel. The size of NPs prepared in this study was in the range of 178-286 nm. The MTT assay showed suitable anticancer activity of the NPs.Confocal microscopy showed that gelatine-coated, biotin-targeted MSNs had higher cell uptake into MCF-7 cancer cells.
期刊介绍：
Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs.
Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.
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