Domenico Abelardo, Pasquale Raimondo, Cristina Santonocito, Alessio Barile, Mauro D'Amora, Andrea Esposito, Martina Maria Giambra, Maria Grazia Lumia, Giovanni Mastrangelo, Danilo Menna, Francesco Murgolo, Angelo Pascarella, Rosetta Salvatore, Rosaria Vignale, Sergio Zacà, Gianluca Paternoster
{"title":"尿肝型脂肪酸结合蛋白作为血管内主动脉瘤修复患者急性肾损伤的术后标志物","authors":"Domenico Abelardo, Pasquale Raimondo, Cristina Santonocito, Alessio Barile, Mauro D'Amora, Andrea Esposito, Martina Maria Giambra, Maria Grazia Lumia, Giovanni Mastrangelo, Danilo Menna, Francesco Murgolo, Angelo Pascarella, Rosetta Salvatore, Rosaria Vignale, Sergio Zacà, Gianluca Paternoster","doi":"10.1053/j.jvca.2025.08.020","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the role of urinary liver-type fatty acid binding protein (L-FABP) in early detection of acute kidney injury (AKI) after endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA).</p><p><strong>Design: </strong>Prospective, observational, multicenter study.</p><p><strong>Setting: </strong>Four university hospitals from January 2024 to June 2024.</p><p><strong>Participants: </strong>Fifty-nine hospitalized patients with AAA.</p><p><strong>Interventions: </strong>Patients undergoing EVAR were included. Demographic data, comorbidities, and renal function data were recorded at baseline and after intervention. L-FABP data were collected at baseline and at 6 hours and 24 hours after surgery.</p><p><strong>Measurements and main results: </strong>The cohort had a mean age of 70.2 ± 7.3 years and was predominantly male (84.7%). Positive L-FABP results were observed in 24.1% of patients at 6 hours post-EVAR and in 23.7% at 24 hours post-EVAR. A positive L-FABP status at both time points was significantly associated with elevated postoperative serum creatinine (SCr) and reduced estimated glomerular filtration rate (eGFR) (p ≤ 0.015), reduced urine output (p = 0.009 and p < 0.001), and shorter hospital length of stay (LOS) (p = 0.004 and p = 0.013). Multivariable logistic regression analysis fully confirmed these associations. Predictive models incorporating L-FABP achieved high accuracy for identifying patients with reduced diuresis (up to 86.1%). Additionally, L-FABP at 6 hours and 24 hours predicted LOS, whereas SCr and eGFR values did not.</p><p><strong>Conclusion: </strong>Urinary L-FABP is emerging as a sensitive biomarker for AKI in patients undergoing EVAR.</p>","PeriodicalId":15176,"journal":{"name":"Journal of cardiothoracic and vascular anesthesia","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urinary Liver-Type Fatty Acid Binding Protein as a Postoperative Marker of Acute Kidney Injury in Patients Undergoing EndovascularAortic Aneurysm Repair.\",\"authors\":\"Domenico Abelardo, Pasquale Raimondo, Cristina Santonocito, Alessio Barile, Mauro D'Amora, Andrea Esposito, Martina Maria Giambra, Maria Grazia Lumia, Giovanni Mastrangelo, Danilo Menna, Francesco Murgolo, Angelo Pascarella, Rosetta Salvatore, Rosaria Vignale, Sergio Zacà, Gianluca Paternoster\",\"doi\":\"10.1053/j.jvca.2025.08.020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the role of urinary liver-type fatty acid binding protein (L-FABP) in early detection of acute kidney injury (AKI) after endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA).</p><p><strong>Design: </strong>Prospective, observational, multicenter study.</p><p><strong>Setting: </strong>Four university hospitals from January 2024 to June 2024.</p><p><strong>Participants: </strong>Fifty-nine hospitalized patients with AAA.</p><p><strong>Interventions: </strong>Patients undergoing EVAR were included. Demographic data, comorbidities, and renal function data were recorded at baseline and after intervention. L-FABP data were collected at baseline and at 6 hours and 24 hours after surgery.</p><p><strong>Measurements and main results: </strong>The cohort had a mean age of 70.2 ± 7.3 years and was predominantly male (84.7%). Positive L-FABP results were observed in 24.1% of patients at 6 hours post-EVAR and in 23.7% at 24 hours post-EVAR. A positive L-FABP status at both time points was significantly associated with elevated postoperative serum creatinine (SCr) and reduced estimated glomerular filtration rate (eGFR) (p ≤ 0.015), reduced urine output (p = 0.009 and p < 0.001), and shorter hospital length of stay (LOS) (p = 0.004 and p = 0.013). Multivariable logistic regression analysis fully confirmed these associations. Predictive models incorporating L-FABP achieved high accuracy for identifying patients with reduced diuresis (up to 86.1%). Additionally, L-FABP at 6 hours and 24 hours predicted LOS, whereas SCr and eGFR values did not.</p><p><strong>Conclusion: </strong>Urinary L-FABP is emerging as a sensitive biomarker for AKI in patients undergoing EVAR.</p>\",\"PeriodicalId\":15176,\"journal\":{\"name\":\"Journal of cardiothoracic and vascular anesthesia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cardiothoracic and vascular anesthesia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1053/j.jvca.2025.08.020\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cardiothoracic and vascular anesthesia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1053/j.jvca.2025.08.020","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
Urinary Liver-Type Fatty Acid Binding Protein as a Postoperative Marker of Acute Kidney Injury in Patients Undergoing EndovascularAortic Aneurysm Repair.
Objective: To evaluate the role of urinary liver-type fatty acid binding protein (L-FABP) in early detection of acute kidney injury (AKI) after endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA).
Setting: Four university hospitals from January 2024 to June 2024.
Participants: Fifty-nine hospitalized patients with AAA.
Interventions: Patients undergoing EVAR were included. Demographic data, comorbidities, and renal function data were recorded at baseline and after intervention. L-FABP data were collected at baseline and at 6 hours and 24 hours after surgery.
Measurements and main results: The cohort had a mean age of 70.2 ± 7.3 years and was predominantly male (84.7%). Positive L-FABP results were observed in 24.1% of patients at 6 hours post-EVAR and in 23.7% at 24 hours post-EVAR. A positive L-FABP status at both time points was significantly associated with elevated postoperative serum creatinine (SCr) and reduced estimated glomerular filtration rate (eGFR) (p ≤ 0.015), reduced urine output (p = 0.009 and p < 0.001), and shorter hospital length of stay (LOS) (p = 0.004 and p = 0.013). Multivariable logistic regression analysis fully confirmed these associations. Predictive models incorporating L-FABP achieved high accuracy for identifying patients with reduced diuresis (up to 86.1%). Additionally, L-FABP at 6 hours and 24 hours predicted LOS, whereas SCr and eGFR values did not.
Conclusion: Urinary L-FABP is emerging as a sensitive biomarker for AKI in patients undergoing EVAR.
期刊介绍：
The Journal of Cardiothoracic and Vascular Anesthesia is primarily aimed at anesthesiologists who deal with patients undergoing cardiac, thoracic or vascular surgical procedures. JCVA features a multidisciplinary approach, with contributions from cardiac, vascular and thoracic surgeons, cardiologists, and other related specialists. Emphasis is placed on rapid publication of clinically relevant material.
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