{"title":"环氧树脂对人体的生物效应:毒性和过敏反应。","authors":"Maria Zofia Lisiecka","doi":"10.1080/01480545.2025.2557405","DOIUrl":null,"url":null,"abstract":"<p><p>This research focused on assessing the impact of epoxy resin components on human health and formulating measures to mitigate their adverse effects. The investigation highlighted the primary routes of exposure to toxic substances, including the inhalation of volatile compounds and direct contact with skin or mucous membranes. The most hazardous components were identified as epichlorohydrin, bisphenol A, and amine hardeners, which were associated with both immediate and long-term toxic effects, such as irritation, inflammatory responses, and the potential for tissue accumulation. Particular attention was directed to sensitization processes resulting from the interaction of epoxy resin constituents with proteins in the skin or mucous membranes, leading to allergic responses like contact dermatitis and systemic sensitization. Additionally, the study examined the influence of occupational settings on the toxicity of these substances, with a focus on measuring the levels of volatile organic compounds present in workplace environments. The study integrated a comprehensive review of scientific literature, experimental findings, and an assessment of toxicity, with a particular focus on industrial applications. Based on the findings, practical recommendations were proposed, including the implementation of personal protective equipment, the automation of production processes, the substitution of hazardous components with safer alternatives, and the establishment of monitoring systems to safeguard worker health. These outcomes are applicable in the manufacturing and utilization of epoxy resins, aiming to mitigate health hazards and enhance environmental sustainability.</p>","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-11"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biological effects of epoxy resins on the human body: toxicity and allergic reactions.\",\"authors\":\"Maria Zofia Lisiecka\",\"doi\":\"10.1080/01480545.2025.2557405\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This research focused on assessing the impact of epoxy resin components on human health and formulating measures to mitigate their adverse effects. The investigation highlighted the primary routes of exposure to toxic substances, including the inhalation of volatile compounds and direct contact with skin or mucous membranes. The most hazardous components were identified as epichlorohydrin, bisphenol A, and amine hardeners, which were associated with both immediate and long-term toxic effects, such as irritation, inflammatory responses, and the potential for tissue accumulation. Particular attention was directed to sensitization processes resulting from the interaction of epoxy resin constituents with proteins in the skin or mucous membranes, leading to allergic responses like contact dermatitis and systemic sensitization. Additionally, the study examined the influence of occupational settings on the toxicity of these substances, with a focus on measuring the levels of volatile organic compounds present in workplace environments. The study integrated a comprehensive review of scientific literature, experimental findings, and an assessment of toxicity, with a particular focus on industrial applications. Based on the findings, practical recommendations were proposed, including the implementation of personal protective equipment, the automation of production processes, the substitution of hazardous components with safer alternatives, and the establishment of monitoring systems to safeguard worker health. These outcomes are applicable in the manufacturing and utilization of epoxy resins, aiming to mitigate health hazards and enhance environmental sustainability.</p>\",\"PeriodicalId\":11333,\"journal\":{\"name\":\"Drug and Chemical Toxicology\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug and Chemical Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/01480545.2025.2557405\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug and Chemical Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01480545.2025.2557405","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Biological effects of epoxy resins on the human body: toxicity and allergic reactions.
This research focused on assessing the impact of epoxy resin components on human health and formulating measures to mitigate their adverse effects. The investigation highlighted the primary routes of exposure to toxic substances, including the inhalation of volatile compounds and direct contact with skin or mucous membranes. The most hazardous components were identified as epichlorohydrin, bisphenol A, and amine hardeners, which were associated with both immediate and long-term toxic effects, such as irritation, inflammatory responses, and the potential for tissue accumulation. Particular attention was directed to sensitization processes resulting from the interaction of epoxy resin constituents with proteins in the skin or mucous membranes, leading to allergic responses like contact dermatitis and systemic sensitization. Additionally, the study examined the influence of occupational settings on the toxicity of these substances, with a focus on measuring the levels of volatile organic compounds present in workplace environments. The study integrated a comprehensive review of scientific literature, experimental findings, and an assessment of toxicity, with a particular focus on industrial applications. Based on the findings, practical recommendations were proposed, including the implementation of personal protective equipment, the automation of production processes, the substitution of hazardous components with safer alternatives, and the establishment of monitoring systems to safeguard worker health. These outcomes are applicable in the manufacturing and utilization of epoxy resins, aiming to mitigate health hazards and enhance environmental sustainability.
期刊介绍:
Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal.
Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.