流行病学揭示铁脓毒症与人群健康的关系。

IF 10.8 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Randi Marie Mohus, Lise T Gustad, Jan Kristian Damås, Hal Drakesmith
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引用次数: 0

摘要

脓毒症是世界范围内死亡和残疾的主要原因,因此确定可预防的风险因素非常重要。铁对免疫功能和微生物生长至关重要,铁的状态在个体之间、人口统计学上存在很大差异,并且可以通过治疗来改变。在这里,我们回顾了目前对铁状态和血流感染、败血症和严重COVID-19相关风险的理解,重点介绍了相关的基于人群的研究和孟德尔随机化研究。低铁和高铁状态都与败血症的风险增加有关。铁含量低与败血症、血液感染和肺炎有关。高铁状态和影响肝磷脂调节的突变与血液感染、败血症和COVID-19风险增加有关。铁状态病理和败血症都是全球性的健康问题,所描述的流行病学研究表明它们可能存在联系。有必要开展更多人口规模的铁状况、感染和免疫调查,特别是在高铁缺乏和感染负担地区。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Iron-sepsis associations in population health revealed by epidemiology.

Sepsis is a leading cause of death and disability worldwide, so identifying preventable risk factors is important. Iron is essential for immune function and microbial growth, and iron status varies substantially between individuals, across demographics, and is therapeutically modifiable. Here, we review the current understanding of iron status and associated risks of bloodstream infection, sepsis and severe COVID-19 highlighting relevant population-based studies and Mendelian randomisation studies. Both low and high iron status are associated with increased risk of sepsis. Low iron status is associated with sepsis, bloodstream infections and pneumonia. High iron status and mutations affecting hepcidin regulation are linked to increased risk of bloodstream infections, sepsis and COVID-19. Both iron status pathologies and sepsis are global health issues, and the epidemiological studies described indicate they may be linked. More population-scale investigations on iron status, infection and immunity, especially in areas of high iron deficiency and infectious burden are warranted.

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来源期刊
EBioMedicine
EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍: eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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