Fernanda M Orduña-Medina, Lorena Díaz de León-Martinez, Grecia D D Alarcón-Rivera, Nancy Angélica Prieto-Gómez, Boris Mizaikoff, Luz E Alcántara-Quintana
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引用次数: 0
摘要
乳腺癌是全世界妇女死亡的主要原因，主要原因是早期发现和获得及时治疗的机会有限。虽然乳房x光检查被广泛使用，但它可能产生假阳性结果并导致过度诊断。最近的进展表明，基于挥发性有机化合物（VOCs）检测的电子鼻技术可能为乳腺癌筛查提供一种补充的非侵入性方法。本系统综述评估了当前的检测方法，探讨了电子鼻的可行性和诊断价值，评估了其与现有临床策略的整合。方法：研究设计：按照PRISMA指南进行系统评价。入选标准：纳入了76篇原创文章，以及8项额外研究的数据。合格的研究以英语或西班牙语发表，评估挥发性有机化合物作为乳腺癌筛查方法，并报告已确定的挥发性有机化合物。排除了系统评价、重复、社论和没有全文访问的文章。信息来源和搜索策略：检索于2024年9月至10月在PubMed、Web of Science、Wiley Online Library和Science Direct进行。关键词：挥发性有机化合物，呼吸生物标志物，挥发组学，乳腺癌，乳腺癌，筛查，检测，电子鼻。共检索到581篇文章：64篇来自PubMed， 44篇来自Web of Science， 152篇来自Wiley， 321篇来自Science Direct。研究选择：采用Zotero进行对照管理和重复去除。两位审稿人独立筛选标题和摘要；审查了符合条件的全文，并协商一致解决了差异。数据提取：采用标准化表格收集作者、出版年份、人群、干预、比较物、主要结果和分析相关数据。三位审稿人独立完成了提取。
Utility of Volatile Organic Compounds and Electronic Nose Technology for Breast Cancer Detection: A Systematic Review.
Breast cancer is a leading cause of mortality in women worldwide, primarily due to challenges in early detection and limited access to timely treatment. While mammography is widely used, it may produce false positives and lead to overdiagnosis. Recent advancements suggest that electronic nose technology, based on the detection of volatile organic compounds (VOCs), may offer a complementary non-invasive approach to breast cancer screening. This systematic review evaluates current detection methods and explores the feasibility and diagnostic value of the electronic nose, assessing its integration into existing clinical strategies.
Methods:
Study design: A systematic review was conducted following PRISMA guidelines.
Eligibility criteria: Seventy-six original articles were included, alongside data from eight additional studies. Eligible studies were published in English or Spanish, evaluated VOCs as a breast cancer screening method, and reported identified VOCs. Systematic reviews, duplicates, editorials, and articles without full-text access were excluded. Information sources and search strategy: Searches were conducted in PubMed, Web of Science, Wiley Online Library, and Science Direct between September and October 2024. Keywords included: volatile organic compounds, breath biomarkers, volatolomics, breast cancer, breast carcinoma, screening, detection, and electronic nose. A total of 581 articles were retrieved: 64 from PubMed, 44 from Web of Science, 152 from Wiley, and 321 from Science Direct.
Study selection: Zotero was used for reference management and duplicate removal. Two reviewers independently screened titles and abstracts; eligible full texts were reviewed, and discrepancies resolved by consensus.
Data extraction: A standardized form was used to collect author, publication year, population, intervention, comparator, main results, and analysis-relevant data. Three reviewers performed the extraction independently.
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