聚（l-蛋氨酸亚砜）-b-聚（脱氢丙氨酸）囊泡的形状转变

IF 5.2 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2025-09-17 DOI:10.1021/acsmacrolett.5c00527

Casey A. Morrison, Timothy J. Deming

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引用次数: 0

摘要

将聚合物囊泡控制转化为稳定的非球形形态是模拟细胞、制造纳米反应器和提高其治疗递送应用潜力的一种手段。我们发现聚（l-蛋氨酸亚砜）x-b-聚（脱氢丙氨酸）y， MOxADHy共肽中的聚（脱氢丙氨酸）片段形成膜，在DMSO/水混合物中提供可塑性和选择性渗透性，这使得通过透析条件的变化可以预测控制囊泡形状。本研究的发现将囊泡形状转化方法扩展到这些可生物降解的嵌段共聚物囊泡，这些囊泡适合于开发用于治疗递送的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Shape Transformation of Poly(l-methionine sulfoxide)-b-poly(dehydroalanine) Vesicles

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Shape Transformation of Poly(l-methionine sulfoxide)-b-poly(dehydroalanine) Vesicles

The controlled transformation of polymeric vesicles into stable nonspherical morphologies is of interest as a means to mimic cells, create nanoreactors, and improve their potential for therapeutic delivery applications. We have found that the poly(dehydroalanine) segments in poly(l-methionine sulfoxide)_x-b-poly(dehydroalanine)_y, M^O_xA^DH_y, copolypeptides form membranes that provide plasticity and selective permeability in DMSO/water mixtures, which allow the predictable control of vesicle shape by the variation of dialysis conditions. The findings of this study expand vesicle shape transformation methods to these biodegradable block copolypeptide vesicles, which are amenable to development for applications in therapeutic delivery.

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.