[基于全球疾病负担数据库的15 - 49岁人群软组织和骨外肉瘤全球负担分析]。

Q3 Medicine

中华预防医学杂志 Pub Date : 2025-09-06 DOI:10.3760/cma.j.cn112150-20250319-00221

Q Z Chen, H H Yu, Y Wang, H Li

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引用次数: 0

摘要

目的：系统分析1990 - 2021年全球和中国大陆15-49岁人群的软组织和骨外肉瘤（STEOS）疾病负担，探讨社会经济发展与疾病负担的关系。方法：从全球疾病负担（GBD2021）数据库中收集15至49岁人群中STEOS的发病率、死亡率和残疾调整生命年（DALY）。采用年均百分比变化（AAPC）量化疾病负担的时间趋势。采用社会人口指数（SDI）来考察社会经济发展。结果：全球15-49岁人群STEOS发病率保持相对稳定（AAPC=-0.13, 95%CI:-0.23—0.04，P=0.299）。死亡率（AAPC=-0.39, 95%CI:-0.47 ~ 0.31, PCI:-0.54 ~ 0.38, PCI:-0.31 ~ 0.10， P=0.314）、死亡率（AAPC=-1.42, 95%CI:-1.59 ~ 1.25, PCI:-1.82 ~ 1.42, PUI:1.28/10万~ 1.46/10万）、死亡率（0.42/10万，95%UI:0.39/10万~ 0.43/10万）和DALY（23.05/10万，95%UI:21.84/10万~ 24.00/10万）均有显著下降，而低sdi地区的死亡率较高(0.36/10万，95%UI:0.27/ 100,000 -0.54/ 100,000)和DALY率（20.50/ 100,000,95%UI:15.46/ 100,000 -30.96/ 100,000）。结论：全球及中国大陆15 ~ 49岁人群STEOS疾病负担持续下降。值得注意的是，到2021年，STEOS将构成重大的疾病负担，特别是在高sdi和低sdi的国家和地区。

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[Analysis of the global burden of soft tissue and extraosseous sarcomas among individuals aged from 15 to 49 based on global burden of disease database].

Objective: To systematically analyze the disease burden of soft tissue and extraosseous sarcomas (STEOS) among individuals aged 15-49 years old worldwide and in the Chinese mainland from 1990 to 2021, and explore the relationship between socio-economic development and disease burden. Methods: Incidence, mortality and disability-adjusted life year (DALY) for STEOS in populations aged from 15 to 49 were collected from the Global Burden of Disease (GBD2021) database. The temporal trends in disease burden were quantified using the average annual percentage change (AAPC). The socio-demographic index (SDI) was employed to examine the socio-economic development. Results: The global incidence rate of STEOS among individuals aged 15-49 remained relatively stable (AAPC=-0.13, 95%CI:-0.23--0.04, P=0.299). In contrast, significant declines were observed in both mortality rate (AAPC=-0.39, 95%CI:-0.47--0.31, P<0.001) and DALY rate (AAPC=-0.46, 95%CI:-0.54--0.38, P<0.001). In the Chinese mainland, the incidence of STEOS among individuals aged 15-49 remained relatively stable (AAPC=-0.10, 95%CI:-0.31-0.10, P=0.314), while the mortality rate (AAPC=-1.42, 95%CI:-1.59--1.25, P<0.001) and DALY rate (AAPC=-1.62, 95%CI:-1.82--1.42, P<0.001) declined steadily from 1990 to 2021. In 2021, high-SDI regions reported high incidence rate (1.38/100 000, 95%UI:1.28/100 000-1.46/100 000), mortality rate (0.42/100 000, 95%UI:0.39/100 000-0.43/100 000) and DALY rate (23.05/100 000, 95%UI:21.84/100 000-24.00/100 000), while low-SDI regions reported high mortality rate (0.36/100 000, 95%UI:0.27/100 000-0.54/100 000) and DALY rate (20.50/100 000, 95%UI:15.46/100 000-30.96/100 000). Conclusion: The disease burden of STEOS worldwide and in the Chinese mainland populations aged from 15 to 49 has declined consistently. Notably, STEOS constitutes a substantial disease burden, particularly among countries and regions with high-SDI and low-SDI in 2021.

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来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.