糖尿病视网膜病变中筛板厚度与视盘血管密度的相关性。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-09-13 DOI:10.1016/j.pdpdt.2025.105219

Doruk Can SEVÜK , Ferhat Baver Polat , Hüseyin Emek , Çimen Baran , Seyfettin Erdem , Sedat Ava , Uğur Keklikçi

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引用次数: 0

摘要

前言：探讨糖尿病视网膜病变（DR）视盘血管密度是否与筛板厚度和深度相关。材料方法：本前瞻性研究共纳入85例受试者，其中对照组30例（1组），非增殖性DR 30例（NPDR= 2组），增殖性DR 25例（PDR= 3组）。进行详细的眼科检查，测量并记录视盘血管密度（OCTA）、视网膜神经纤维厚度（OCT）、增强深度成像OCT （edii -OCT）网膜厚度和深度、层前组织厚度和Bruch膜开口。组间比较采用方差分析t检验，参数间关系采用Spearman相关分析。结果：两组患者年龄、性别差异无统计学意义（p=0.741, p=0.922）。EDI-OCT显示，2、3组糖尿病视网膜病变与网膜厚度无相关性(p)。而筛板深度、层前组织厚度与Bruch膜开度有相关性。通过在糖尿病患者的EDI-OCT中进行这些相关测量，可以获得视盘血管是否受到影响的信息。

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Correlation of lamina cribrosa thickness and optic disc vascular density in diabetic retinopathy

Introduction

To determine whether optic disc vascular density correlates with lamina cribrosa thickness and depth in diabetic retinopathy (DR).

Materials Method

A total of 85 participants, 30 controls (Group-1), 30 with nonproliferative DR (NPDR=Group-2) and 25 with proliferative DR (PDR=Group-3) were included in this prospective study. Detailed ophthalmologic examinations were performed, optic disc vascular density by optical coherence tomography angiography (OCTA), retinal nerve fiber thickness by OCT, lamina cribrosa thickness and depth by enhanced depth imaging OCT (EDI-OCT), prelaminar tissue thickness, and Bruch's membrane openings were measured and recorded. Groups were compared with ANOVA t-test and the relationship between the parameters was evaluated with Spearman's correlation analysis.

Results

No statistically significant difference was found between the groups in terms of age and gender (p=0.741, p=0.922, respectively). In EDI-OCT, lamina cribrosa depth was significantly decreased in groups 2 and 3 (p<0.001). No statistically significant difference was observed between the groups in terms of lamina cribrosa thickness (p=0.115). Prelaminar tissue thickness was significantly thinner in Groups 2 and 3 (p<0.001). Bruch's membrane opening was significantly higher in Groups 2 and 3 (p=0.001). It was observed that the percentage of vascular density was significantly decreased in the inside disc, peripapillary, whole optic disc and inferior hemi in the groups with DR compared to healthy subjects (p<0.001), while the percentage of vascular density in the inside disc and whole optic disc images was correlated with proliferation. Retinal nerve fiber thickness and lamina cribrosa depth were significantly negatively correlated (r:-0.228 p=0.036).

Conclusion

There was no correlation between diabetic retinopathy and lamina cribrosa thickness. However, there was a correlation between lamina cribrosa depth, prelaminar tissue thickness and Bruch's membrane opening. By performing these correlated measurements in EDI-OCT in diabetic patients, information about whether optic disc vascularity is affected can be obtained.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.