两种海水衍生镁制剂的生物利用度比较。

IF 2 3区 农林科学 Q4 CHEMISTRY, MEDICINAL
Brian K McFarlin, Anyla L Paschall, Molly E Kelly, Stephanie M Womack
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引用次数: 0

摘要

镁缺乏是一个世界性的普遍问题;然而,现有的镁膳食补充剂来源需要大剂量来克服低生物利用度。此前的研究已经证实,海水中除了含有72种其他微量和超微量矿物质外,还含有镁,因此比传统的镁源具有更好的生物利用度。本研究的目的是比较两种不同的海水处理方法(氢氧化物和柠檬酸盐)所获得的镁的生物利用度。以双盲方式,健康的年轻男性和女性(N = 20)使用交叉设计完成了三项试验:安慰剂(麦芽糊精)、海水柠檬酸镁(Aquamin®-Mg;微量10%元素镁)和海水衍生氢氧化镁(Aquamin®-MgTg;微量33%元素镁)。镁的总剂量以每日推荐摄入量(RDA)为标准。采用渐进式18 h尿镁排泄试验评估镁的相对生物利用度。尿摄取通过短期血清镁测量(摄入后1和2小时)来验证。用比色法分析三份副本的血清和尿镁浓度。我们发现,与安慰剂相比,两种海水衍生的镁制剂都显著增加了镁的吸收(变化幅度为97%),但当镁剂量标准化时,两者之间没有差异。氢氧化镁的形式可能特别有用,因为与可溶性柠檬酸镁相比,其较高的镁含量允许摄入较少的总量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing the Bioavailability of Two Seawater-Derived Magnesium Preparations.

Magnesium deficiency is a common problem worldwide; however, existing magnesium dietary supplement sources require large doses to overcome low bioavailability. Previously research has established that seawater contains magnesium in addition to 72 other trace and ultratrace minerals, resulting in better bioavailability than traditional magnesium sources. The purpose of the present study was to compare the bioavailability of magnesium obtained from two different seawater processing methods (hydroxide vs. citrate). In a double-blind manner, healthy, young men and women (N = 20) completed three trials using a crossover design: placebo (maltodextrin), seawater magnesium citrate (Aquamin®-Mg; min 10% elemental magnesium), and seawater-derived magnesium hydroxide (Aquamin®-MgTg; min 33% elemental magnesium). Total magnesium doses were standardized on the Recommended Daily Allowance (RDA) for elemental magnesium. An incremental, 18-h urine magnesium excretion test was used to assess relative magnesium bioavailability. The urine uptake was verified by short-term serum magnesium measurements (1- and 2-h postingestion). Serum and urine magnesium concentration were analyzed in triplicate using a colorimetric assay. We found that both seawater-derived magnesium preparations significantly increased magnesium absorption compared with placebo (>97% change) but did not differ from each other when standardized on magnesium dose. The magnesium hydroxide form may be particularly useful since its greater magnesium content allows for ingestion of smaller total quantities compared to soluble magnesium citrate.

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来源期刊
Journal of medicinal food
Journal of medicinal food 医学-食品科技
CiteScore
4.50
自引率
0.00%
发文量
154
审稿时长
4.5 months
期刊介绍: Journal of Medicinal Food is the only peer-reviewed journal focusing exclusively on the medicinal value and biomedical effects of food materials. International in scope, the Journal advances the knowledge of the development of new food products and dietary supplements targeted at promoting health and the prevention and treatment of disease.
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