Shuo-Guo Li, Zheng-Ran Zou, Jing-Yu Quan, Xiao-Feng Zheng, An-Qi Hu, Xu-Hua Yu, Zi-Yao Liang, Yue Sun, Lin Lin, Shu-Mei Wang, Long Fan
{"title":"一种新型抗炎单萜类吲哚生物碱。","authors":"Shuo-Guo Li, Zheng-Ran Zou, Jing-Yu Quan, Xiao-Feng Zheng, An-Qi Hu, Xu-Hua Yu, Zi-Yao Liang, Yue Sun, Lin Lin, Shu-Mei Wang, Long Fan","doi":"10.1080/10286020.2025.2558638","DOIUrl":null,"url":null,"abstract":"<p><p>Two monoterpenoid indole alkaloids including one undescribed alkaloid, naucleficine B (<b>1</b>), and a known alkaloid glycoside, strictosamide (<b>2</b>) were isolated from ethyl acetate fraction of the 95% ethanol extract from the trunk of <i>Nauclea officinalis</i>, together with three known non-alkaloid components, (+)-medioresinol (<b>3</b>), protocatechuic acid (<b>4</b>), and benzoic acid (<b>5</b>). Their structures were elucidated on the basis of extensive spectroscopic analysis and X-ray diffraction. Compounds <b>1</b> and <b>2</b> exhibited potent anti-inflammatory effects in cigarette smoke extract (CSE)-stimulated RAW 264.7 and THP-1 macrophages. These compounds significantly suppressed nitric oxide (NO) generation, reduced the secretion of inflammatory mediators, and inhibited the activation of inflammation-related proteins.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A new anti-inflammatory monoterpenoid indole alkaloid from the trunk of <i>Nauclea officinalis</i>.\",\"authors\":\"Shuo-Guo Li, Zheng-Ran Zou, Jing-Yu Quan, Xiao-Feng Zheng, An-Qi Hu, Xu-Hua Yu, Zi-Yao Liang, Yue Sun, Lin Lin, Shu-Mei Wang, Long Fan\",\"doi\":\"10.1080/10286020.2025.2558638\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Two monoterpenoid indole alkaloids including one undescribed alkaloid, naucleficine B (<b>1</b>), and a known alkaloid glycoside, strictosamide (<b>2</b>) were isolated from ethyl acetate fraction of the 95% ethanol extract from the trunk of <i>Nauclea officinalis</i>, together with three known non-alkaloid components, (+)-medioresinol (<b>3</b>), protocatechuic acid (<b>4</b>), and benzoic acid (<b>5</b>). Their structures were elucidated on the basis of extensive spectroscopic analysis and X-ray diffraction. Compounds <b>1</b> and <b>2</b> exhibited potent anti-inflammatory effects in cigarette smoke extract (CSE)-stimulated RAW 264.7 and THP-1 macrophages. These compounds significantly suppressed nitric oxide (NO) generation, reduced the secretion of inflammatory mediators, and inhibited the activation of inflammation-related proteins.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-16\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2025.2558638\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2558638","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
A new anti-inflammatory monoterpenoid indole alkaloid from the trunk of Nauclea officinalis.
Two monoterpenoid indole alkaloids including one undescribed alkaloid, naucleficine B (1), and a known alkaloid glycoside, strictosamide (2) were isolated from ethyl acetate fraction of the 95% ethanol extract from the trunk of Nauclea officinalis, together with three known non-alkaloid components, (+)-medioresinol (3), protocatechuic acid (4), and benzoic acid (5). Their structures were elucidated on the basis of extensive spectroscopic analysis and X-ray diffraction. Compounds 1 and 2 exhibited potent anti-inflammatory effects in cigarette smoke extract (CSE)-stimulated RAW 264.7 and THP-1 macrophages. These compounds significantly suppressed nitric oxide (NO) generation, reduced the secretion of inflammatory mediators, and inhibited the activation of inflammation-related proteins.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
