评估小母亲抗十足瘫3和转化生长因子β水平与治疗后肺结核患者肺纤维化和功能的关系。

IF 1.5 Q4 INFECTIOUS DISEASES
International Journal of Mycobacteriology Pub Date : 2025-07-01 Epub Date: 2025-09-15 DOI:10.4103/ijmy.ijmy_60_25
Harry Akza Putrawan, Irfan Idris, Arif Santoso, Harun Iskandar, Zainul Muttaqin, Jamal Zaini, Rosdiana Natzir, Uleng Bahrun, Suryani Tawali
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引用次数: 0

摘要

结核病(TB)是一个重要的全球健康问题,治疗后纤维化对肺功能和患者生活质量产生负面影响。本研究调查了结核病后肺纤维化的驱动过程及其对患者的影响。方法:本研究纳入38例接受2个月强化治疗的肺结核患者。采用酶联免疫吸附测定法定量治疗前后转化生长因子β (TGFβ)和小母抗十肢截瘫3 (SMAD3)水平。通过胸部成像评估纤维化,通过肺活量测定法评估肺功能。结果:治疗后TGFβ和SMAD3水平明显降低(P = 0.03和P = 0.01)。干预后SMAD3水平与纤维化发生(P = 0.03)和肺功能下降(P = 0.01)存在显著相关。受试者操作特征分析显示,干预后SMAD3曲线下面积为0.8,敏感性为87%,特异性为71%,提示其作为纤维化生物标志物的潜力。结论:肺结核治疗后TGFβ和SMAD3水平与纤维化和肺功能降低有关。干预后的SMAD3可能是肺结核患者的纤维化生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Small Mothers against Decapentaplegic 3 and Transforming Growth Factor Beta Levels in Relation to Lung Fibrosis and Function in Treated Pulmonary Tuberculosis Patients.

Introduction: Tuberculosis (TB) is a significant global health issue, with posttreatment fibrosis negatively affecting pulmonary function and patient quality of life. This research investigated the processes driving post-TB pulmonary fibrosis and its impact on patients.

Methods: This research involved a cohort of 38 pulmonary TB patients undergoing intensive treatment for 2 months. Transforming Growth Factor Beta (TGFβ) and Small Mothers Against Decapentaplegic 3 (SMAD3) levels were quantified pre- and posttreatment using the Enzyme Linked Immuno Sorbent Assay method. Fibrosis was evaluated via thoracic imaging, and lung function was assessed through spirometry.

Results: TGFβ and SMAD3 levels were decreased post-treatment (P = 0.03 and P = 0.01). A significant association existed between postintervention SMAD3 levels and the occurrence of fibrosis (P = 0.03) and diminished lung function (P = 0.01). Receiver operating characteristic analysis indicated that post-intervention SMAD3 exhibited an area under the curve of 0.8, with a sensitivity of 87% and specificity of 71%, suggesting its potential as a biomarker for fibrosis.

Conclusion: Levels of TGFβ and SMAD3 following pulmonary TB treatment are linked to fibrosis and reduced lung function. SMAD3 post-intervention may be a fibrosis biomarker in pulmonary TB patients.

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来源期刊
CiteScore
2.20
自引率
25.00%
发文量
62
审稿时长
7 weeks
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