{"title":"青少年重度抑郁症患者失眠症状与临床特征及血液代谢参数的关系","authors":"Xi Zhang, Lewei Liu, Yun Zhang, Lili Zhao, Jiawei Wang, Changhao Chen, Zhiwei Liu, Feng Geng, Daming Mo, Xiangfen Luo, Xiangwang Wen, Ling Zhang, Huanzhong Liu","doi":"10.1007/s00406-025-02113-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adolescents with major depressive disorder (MDD) frequently experience insomnia (difficulty initiating, maintaining sleep or early awakening). This prevalent symptom may associate with depression, negative life events, childhood maltreatment (CM), and blood metabolic parameters. We investigated associations between insomnia, clinical features, and blood metabolic parameters in adolescents with MDD .</p><p><strong>Methods: </strong>From January 2021 to December 2022, 361 adolescents with MDD aged 12-18 were included in this cross-sectional study. We used the Center for Epidemiological Studies Depression Scale (CES-D), the Insomnia Severity Index Scale (ISI), the Adolescent Self-rating Life Events Checklist (ASLEC), and the Childhood Trauma Questionnaire (CTQ) to assess depression, insomnia, negative Life events, and CM. Additionally, we measured blood metabolic parameters Levels in 150 subjects. Finally, logistic regression analyses and receiver operating characteristic (ROC) curve analyses were conducted.</p><p><strong>Results: </strong>Among adolescents with MDD, the prevalence of insomnia was 37.4%. Compared with the non-insomnia, patients in the insomnia had a greater propensity to live in families with abnormal parental marital status, to have attempted suicide, and to exhibite higher scores on a series of scales. Further logistic regression analyses revealed that abnormal parental marital status (OR = 2.012, 95% CI = 1.127-3.592), CES-D score (OR = 1.093, 95% CI = 1.063-1.124), healthy adaptation (OR = 1.130, 95% CI = 1.402-1.226), and emotional neglect (OR = 0.941, 95% CI = 0.889-0.996) were independently associated with insomnia. When metabolic parameters were included, thyroid-stimulating hormone (TSH) (OR = 1.730, 95% CI = 1.170-2.558) and 25-hydroxyvitamin D [25(OH)D] (OR = 0.851, 95% CI = 0.758-0.954) were also identified as independent factors influencing insomnia. Additionally, ROC curve analyses showed that the model based solely on clinical features had good predictive performance for insomnia (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001). When metabolic parameters were included, the predictive performance of the model was further improved (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001).</p><p><strong>Conclusion: </strong>Among adolescents with MDD, insomnia are widespread and may correlate with depression, negative Life events, CM, TSH, and 25(OH)D. Therefore, it is necessary to consider these factors comprehensively in clinical interventions.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The associations of insomnia symptoms and clinical features as well as blood metabolic parameters in adolescents with major depressive disorders.\",\"authors\":\"Xi Zhang, Lewei Liu, Yun Zhang, Lili Zhao, Jiawei Wang, Changhao Chen, Zhiwei Liu, Feng Geng, Daming Mo, Xiangfen Luo, Xiangwang Wen, Ling Zhang, Huanzhong Liu\",\"doi\":\"10.1007/s00406-025-02113-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Adolescents with major depressive disorder (MDD) frequently experience insomnia (difficulty initiating, maintaining sleep or early awakening). This prevalent symptom may associate with depression, negative life events, childhood maltreatment (CM), and blood metabolic parameters. We investigated associations between insomnia, clinical features, and blood metabolic parameters in adolescents with MDD .</p><p><strong>Methods: </strong>From January 2021 to December 2022, 361 adolescents with MDD aged 12-18 were included in this cross-sectional study. We used the Center for Epidemiological Studies Depression Scale (CES-D), the Insomnia Severity Index Scale (ISI), the Adolescent Self-rating Life Events Checklist (ASLEC), and the Childhood Trauma Questionnaire (CTQ) to assess depression, insomnia, negative Life events, and CM. Additionally, we measured blood metabolic parameters Levels in 150 subjects. Finally, logistic regression analyses and receiver operating characteristic (ROC) curve analyses were conducted.</p><p><strong>Results: </strong>Among adolescents with MDD, the prevalence of insomnia was 37.4%. Compared with the non-insomnia, patients in the insomnia had a greater propensity to live in families with abnormal parental marital status, to have attempted suicide, and to exhibite higher scores on a series of scales. Further logistic regression analyses revealed that abnormal parental marital status (OR = 2.012, 95% CI = 1.127-3.592), CES-D score (OR = 1.093, 95% CI = 1.063-1.124), healthy adaptation (OR = 1.130, 95% CI = 1.402-1.226), and emotional neglect (OR = 0.941, 95% CI = 0.889-0.996) were independently associated with insomnia. When metabolic parameters were included, thyroid-stimulating hormone (TSH) (OR = 1.730, 95% CI = 1.170-2.558) and 25-hydroxyvitamin D [25(OH)D] (OR = 0.851, 95% CI = 0.758-0.954) were also identified as independent factors influencing insomnia. Additionally, ROC curve analyses showed that the model based solely on clinical features had good predictive performance for insomnia (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001). When metabolic parameters were included, the predictive performance of the model was further improved (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001).</p><p><strong>Conclusion: </strong>Among adolescents with MDD, insomnia are widespread and may correlate with depression, negative Life events, CM, TSH, and 25(OH)D. Therefore, it is necessary to consider these factors comprehensively in clinical interventions.</p>\",\"PeriodicalId\":11822,\"journal\":{\"name\":\"European Archives of Psychiatry and Clinical Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Archives of Psychiatry and Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00406-025-02113-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Archives of Psychiatry and Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00406-025-02113-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:重度抑郁障碍(MDD)青少年经常经历失眠(难以启动、维持睡眠或早醒)。这种普遍症状可能与抑郁、负面生活事件、童年虐待(CM)和血液代谢参数有关。我们调查了青少年重度抑郁症患者失眠、临床特征和血液代谢参数之间的关系。方法:从2021年1月到2022年12月,361名12-18岁的MDD青少年纳入了这项横断面研究。我们使用流行病学研究中心抑郁量表(CES-D)、失眠严重程度指数量表(ISI)、青少年生活事件自评表(ASLEC)和儿童创伤问卷(CTQ)来评估抑郁、失眠、消极生活事件和CM。此外,我们测量了150名受试者的血液代谢参数水平。最后进行logistic回归分析和受试者工作特征(ROC)曲线分析。结果:MDD青少年中失眠患病率为37.4%。与非失眠症患者相比,失眠症患者更倾向于生活在父母婚姻状况异常的家庭中,更倾向于企图自杀,并且在一系列量表中表现出更高的得分。进一步的logistic回归分析显示,父母婚姻状况异常(OR = 2.012, 95% CI = 1.127 ~ 3.592)、ce - d评分(OR = 1.093, 95% CI = 1.063 ~ 1.124)、健康适应(OR = 1.130, 95% CI = 1.402 ~ 1.226)、情绪忽视(OR = 0.941, 95% CI = 0.889 ~ 0.996)与失眠独立相关。当纳入代谢参数时,促甲状腺激素(TSH) (OR = 1.730, 95% CI = 1.170 ~ 2.558)和25-羟基维生素D [25(OH)D] (OR = 0.851, 95% CI = 0.758 ~ 0.954)也是影响失眠的独立因素。此外,ROC曲线分析显示,仅基于临床特征的模型对失眠有较好的预测效果(AUC = 0.777, 95% CI = 0.730-0.825, P)。结论:在MDD青少年中,失眠普遍存在,可能与抑郁、负面生活事件、CM、TSH和25(OH)D相关。因此,在临床干预中有必要综合考虑这些因素。
The associations of insomnia symptoms and clinical features as well as blood metabolic parameters in adolescents with major depressive disorders.
Background: Adolescents with major depressive disorder (MDD) frequently experience insomnia (difficulty initiating, maintaining sleep or early awakening). This prevalent symptom may associate with depression, negative life events, childhood maltreatment (CM), and blood metabolic parameters. We investigated associations between insomnia, clinical features, and blood metabolic parameters in adolescents with MDD .
Methods: From January 2021 to December 2022, 361 adolescents with MDD aged 12-18 were included in this cross-sectional study. We used the Center for Epidemiological Studies Depression Scale (CES-D), the Insomnia Severity Index Scale (ISI), the Adolescent Self-rating Life Events Checklist (ASLEC), and the Childhood Trauma Questionnaire (CTQ) to assess depression, insomnia, negative Life events, and CM. Additionally, we measured blood metabolic parameters Levels in 150 subjects. Finally, logistic regression analyses and receiver operating characteristic (ROC) curve analyses were conducted.
Results: Among adolescents with MDD, the prevalence of insomnia was 37.4%. Compared with the non-insomnia, patients in the insomnia had a greater propensity to live in families with abnormal parental marital status, to have attempted suicide, and to exhibite higher scores on a series of scales. Further logistic regression analyses revealed that abnormal parental marital status (OR = 2.012, 95% CI = 1.127-3.592), CES-D score (OR = 1.093, 95% CI = 1.063-1.124), healthy adaptation (OR = 1.130, 95% CI = 1.402-1.226), and emotional neglect (OR = 0.941, 95% CI = 0.889-0.996) were independently associated with insomnia. When metabolic parameters were included, thyroid-stimulating hormone (TSH) (OR = 1.730, 95% CI = 1.170-2.558) and 25-hydroxyvitamin D [25(OH)D] (OR = 0.851, 95% CI = 0.758-0.954) were also identified as independent factors influencing insomnia. Additionally, ROC curve analyses showed that the model based solely on clinical features had good predictive performance for insomnia (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001). When metabolic parameters were included, the predictive performance of the model was further improved (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001).
Conclusion: Among adolescents with MDD, insomnia are widespread and may correlate with depression, negative Life events, CM, TSH, and 25(OH)D. Therefore, it is necessary to consider these factors comprehensively in clinical interventions.
期刊介绍:
The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience.
Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered.
Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.